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Genetic Engineering of Vein Bypass Grafts in Vascular and Cardiovascular Surgery

Description: PROJECT NARRATIVE Injury to the grafts during surgery is a major cause for failure of heart bypass grafts and bypass grafts for peripheral vascular disease. The investigators propose to prevent this failure by genetically engineering the vein graft to reduce harmful and increase protective genes, using state-of-the art techniques that can be applied in the operating room.
Funding type: research
Funder scheme: R01
Start date: 2007-02-01
End date: 2024-12-31
Investigator: MANOJ BHASIN
Institution: BETH ISRAEL DEACONESS MEDICAL CENTER
Funded outputs count: 28
Funder award ID: R01HL086741
OpenAlex ID: G3020105166
2024 · Marina E. Michaud, Lucas Mota, et al. · Circulation Research · 13
2024 · Phillip Brennan, Nyah Patel, et al. · Journal of Visualized Experiments
2024 · Phillip G. Brennan, Lucas Mota, et al. · Annals of Vascular Surgery · 2
2021 · Cleide Angolano, Elzbieta Kaczmarek, et al. · Frontiers in Cardiovascular Medicine · 18
2020 · Franciele Cristina Kipper, Cleide Angolano, et al. · Scientific Reports · 3
2017 · Christoph S. Nabzdyk, Leena Pradhan-Nabzdyk, et al. · Journal of Translational Medicine · 15
2016 · Herwig P. Moll, Andy Lee, et al. · Transplantation · 12
2014 · Leena Pradhan-Nabzdyk, Chenyu Huang, et al. · PubMed · 8
2014 · Leena Pradhan-Nabzdyk, Chenyu Huang, et al. · PubMed · 16
2013 · Renata P. Guedes, Eduardo Rocha, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 6
2012 · Christoph S. Nabzdyk, Maggie Chun, et al. · Biochemical and Biophysical Research Communications · 18
2011 · Shunsuke Yoshida, Christoph S. Nabzdyk, et al. · Journal of the American College of Surgeons · 11
2011 · Christoph S Nabzdyk, Maggie Chun, et al. · Journal of Translational Medicine · 45
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