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Smooth Muscle Myosin Phosphatase Subunit Isoforms

Description: The smooth muscle of the small resistance arteries by contracting and relaxing is the primary regulator of blood flow to the tissues. The proposed experiments will test the role of Transformer proteins, master determinants of sexual features in flies, in regulating gene expression and function of the small arteries in development and disease.

Funder: National Heart, Lung, and Blood Institute

Funding type: research

Funder scheme: R01

Start date: 2001-02-01

End date: 2016-04-30

Investigator: STEVEN A. FISHER

Institution: UNIVERSITY OF MARYLAND BALTIMORE

Funded outputs count: 35

Funder award ID: R01HL066171

OpenAlex ID: G3067874792

An antisense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo

2024 · Celio Damacena de Angelis, Mariam Meddeb, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 7

Bioinformatic analysis of smoothelin family members supports tissue‐specific functions of unique C‐terminal calponin homology domains

2023 · Dhruv Garg, Steven A. Fisher · Physiological Reports

Tissue-specific expression of myosin phosphatase subunits and isoforms in smooth muscle of mice and humans

2022 · Kimberly Oslin, John J. Reho, et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 7

Smooth Muscle Phenotypic Diversity

2016 · S.A. Fisher · Advances in pharmacology · 9

A splice variant of the myosin phosphatase regulatory subunit tunes arterial reactivity and suppresses response to salt loading

2016 · John J. Reho, Doreswamy Kenchegowda, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 12

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A splice variant of smooth muscle myosin phosphatase regulatory subunit tunes arterial reactivity and suppresses response to salt loading

2016 · John Reho, Doreswamy Kenchegowda, et al. · The FASEB Journal

Maternal separation stress causes mis‐programming of arterial smooth muscle maturation

2016 · John Reho, Steven A Fisher · The FASEB Journal

The stress of maternal separation causes misprogramming in the postnatal maturation of rat resistance arteries

2015 · John J. Reho, Steven A. Fisher · American Journal of Physiology-Heart and Circulatory Physiology · 17

Unique gene program of rat small resistance mesenteric arteries as revealed by deep RNA sequencing

2015 · John J. Reho, Amol Shetty, et al. · Physiological Reports · 11

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Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis

2015 · John J. Reho, Xiaoxu Zheng, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 25

TRA2β controls Mypt1 exon 24 splicing in the developmental maturation of mouse mesenteric artery smooth muscle

2014 · Xiaoxu Zheng, John J. Reho, et al. · American Journal of Physiology-Cell Physiology · 18

Neural programming of mesenteric and renal arteries

2014 · John J. Reho, Xiaoxu Zheng, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 22

A bioinformatic and computational study of myosin phosphatase subunit diversity

2014 · Rachael P. Dippold, Steven A. Fisher · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 25

Myosin phosphatase isoforms and related transcripts in the pig coronary circulation and effects of exercise and chronic occlusion

2014 · Xiaoxu Zheng, Cristine L. Heaps, et al. · Microvascular Research · 3

Smooth muscle contractile diversity in the control of regional circulations

2013 · John J. Reho, Xiaoxu Zheng, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 57

Myosin Phosphatase Isoforms as Determinants of Smooth Muscle Contractile Function and Calcium Sensitivity of Force Production

2013 · Rachael P. Dippold, Steven A. Fisher · Microcirculation · 33

Notch Transcriptional Control of Vascular Smooth Muscle Regulatory Gene Expression and Function

2013 · Sanchita Basu, Dinesh Kumar Srinivasan, et al. · Journal of Biological Chemistry · 24

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Conditional inactivation of the splicing regulator Tra2[beta] shifts myosin phosphatase isoforms and enhances smooth muscle sensitivity to cGMP‐mediated relaxation

2012 · Bhupal Bhetwal, Kang Fu, et al. · The FASEB Journal

Tra2β Protein Is Required for Tissue-specific Splicing of a Smooth Muscle Myosin Phosphatase Targeting Subunit Alternative Exon

2012 · Kang Fu, Ylva Mende, et al. · Journal of Biological Chemistry · 23

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Regulation of basal LC20 phosphorylation by MYPT1 and CPI‐17 in murine gastric antrum, gastric fundus, and proximal colon smooth muscles

2011 · B. P. Bhetwal, C. L. An, et al. · Neurogastroenterology & Motility · 30

Vascular smooth muscle phenotypic diversity and function

2010 · Steven A. Fisher · Physiological Genomics · 180

Induction of PDE5 and de-sensitization to endogenous NO signaling in a systemic resistance artery under altered blood flow

2009 · Haiying Zhang, Praveen Pakeerappa, et al. · Journal of Molecular and Cellular Cardiology · 13

Tra2β As a Novel Mediator of Vascular Smooth Muscle Diversification

2008 · Supriya Shukla, Steven A. Fisher · Circulation Research · 32

Discovery of Tra2b splicing factor in a novel pathway regulating vascular smooth phenotypic diversity

2008 · Steven A Fisher, Supriya Shukla · The FASEB Journal

Induction of NOS and PDE5 isozymes in resistance arteries under chronic high and low flow

2008 · Hyon Jae Lee, Haiying Zhang, et al. · The FASEB Journal