Biology and Application of Platelet-Delivered Factor VIII
Description: PUBLIC HEALTH RELEVANCE: The most common inherited bleeding disorder, hemophilia A, is due to a deficiency of clotting factor (F) VIII. Care for this disorder is rapidly improving excpt for those who develop antibodies that block the ability of FVIII to correct bleeding and these antibodies are called inhibitors. We have developed a new treatment for such affected patients with inhibitors by packing the FVIII inside circulating platelets in the blood, but need to now tes the effectiveness of the delivery of FVIII within platelets in hemophilia A animal models, especially in the setting of inhibitors.
Funding type: research
Funder scheme: R01
Start date: 2016-05-01
End date: 2020-04-30
Investigator: MORTIMER PONCZ
Institution: CHILDREN'S HOSP OF PHILADELPHIA
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 7
Funder award ID: R01HL132557
OpenAlex ID: G3083328877