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Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes

Description: PROJECT NARRATIVE We aim to examine stem cell-derived cardiomyocytes in response to a multipronged approach for promotion of cardiomyocyte maturation. Findings from this study will help to address key issues facing applications of cardiomyocytes derived from human pluripotent stem cells in cardiotoxicity testing, disease modeling, developmental biology and regenerative medicine.
Funding type: research
Funder scheme: R01
Start date: 2018-02-01
End date: 2023-01-31
Investigator: CHUNHUI XU
Institution: EMORY UNIVERSITY
Funded outputs count: 18
Funder award ID: R01HL136345
OpenAlex ID: G3175431100
Simulated microgravity improves maturation of cardiomyocytes derived from human induced pluripotent stem cells
2024 · Parvin Forghani, Aysha Rashid, et al. · Scientific Reports · 17
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Space microgravity increases expression of genes associated with proliferation and differentiation in human cardiac spheres
2023 · Hyun Hwang, Antonio Rampoldi, et al. · npj Microgravity · 24
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AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling
2023 · Dong Li, Lawrence C. Armand, et al. · Stem Cell Research & Therapy · 16
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Chronic ethanol exposure induces mitochondrial dysfunction and alters gene expression and metabolism in human cardiac spheroids
2023 · Hyun Hwang, Rui Liu, et al. · Alcoholism Clinical and Experimental Research · 17
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Space microgravity improves proliferation of human iPSC-derived cardiomyocytes
2022 · Antonio Rampoldi, Parvin Forghani, et al. · Stem Cell Reports · 40
Carfilzomib Treatment Causes Molecular and Functional Alterations of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
2021 · Parvin Forghani, Aysha Rashid, et al. · Journal of the American Heart Association · 39
Chronic Ethanol Exposure Induces Deleterious Changes in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells
2021 · Rui Liu, Fangxu Sun, et al. · Stem Cell Reviews and Reports · 19
Downstream bioprocessing of human pluripotent stem cell‐derived therapeutics
2021 · Sebastien Sart, Chang Liu, et al. · Engineering in Life Sciences · 2
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Cryopreservation and CO2-independent culture of 3D cardiac progenitors for spaceflight experiments
2021 · Antonio Rampoldi, Rajneesh Jha, et al. · Biomaterials · 10
Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells
2020 · Rui Liu, Dong Li, et al. · Stem Cell Research & Therapy · 36
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Machine learning identifies abnormal Ca2+ transients in human induced pluripotent stem cell-derived cardiomyocytes
2020 · Hyun Hwang, Rui Liu, et al. · Scientific Reports · 35
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Proteomic Profiling Reveals Roles of Stress Response, Ca2+ Transient Dysregulation, and Novel Signaling Pathways in Alcohol‐Induced Cardiotoxicity
2020 · Rui Liu, Fangxu Sun, et al. · Alcoholism Clinical and Experimental Research · 9
A long non‐coding RNA GATA6‐AS1 adjacent to GATA6 is required for cardiomyocyte differentiation from human pluripotent stem cells
2020 · Rajneesh Jha, Dong Li, et al. · The FASEB Journal · 20
Functional and Molecular Effects of TNF-α on Human iPSC-Derived Cardiomyocytes
2020 · Anita Saraf, Antonio Rampoldi, et al. · Stem Cell Research · 40
Hypoplastic left heart syndrome: From bedside to bench and back
2019 · Anita Saraf, Wendy M. Book, et al. · Journal of Molecular and Cellular Cardiology · 30
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Targeting HIF-1α in combination with PPARα activation and postnatal factors promotes the metabolic maturation of human induced pluripotent stem cell-derived cardiomyocytes
2019 · Cinsley Gentillon, Dong Li, et al. · Journal of Molecular and Cellular Cardiology · 71
Cardiac Toxicity From Ethanol Exposure in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
2019 · Antonio Rampoldi, Monalisa Singh, et al. · Toxicological Sciences · 22
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Targeted Elimination of Tumorigenic Human Pluripotent Stem Cells Using Suicide-Inducing Virus-like Particles
2018 · Antonio Rampoldi, Stephen N. Crooke, et al. · ACS Chemical Biology · 21
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