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Development of a Universal Influenza Vaccine Against Influenza A and B Viruses

Description: NARRATIVE This project focuses on the development of a universal influenza vaccine that can enable protection against all influenza A and B strains, thus eliminating the need for yearly vaccinations against influenza, and the threat of influenza pandemics. Successful completion of the project may in the long run reduce much morbidity, especially amongst elderly and children.
Funding type: research
Funder scheme: R01
Start date: 2018-11-12
End date: 2024-10-31
Investigator: HARVINDER SINGH GILL
Institution: TEXAS TECH UNIVERSITY
Subfield: Epidemiology
Field: Medicine
Funded outputs count: 9
Funder award ID: R01AI137846
OpenAlex ID: G3206594635
Floss-based vaccination targets the gingival sulcus for mucosal and systemic immunization
2025 · Rohan S. J. Ingrole, Akhilesh Kumar Shakya, et al. · Nature Biomedical Engineering · 10
Generation of Broad Protection against Influenza with Di-Tyrosine-Cross-Linked M2e Nanoclusters
2024 · Logan R. Wilks, Gaurav Joshi, et al. · ACS Infectious Diseases · 5
Comparison of Different Stabilizing Agents and Antigen Attachment Methods on Iron Oxide Nanoparticles for Vaccination
2023 · Carsen Roach, Gaurav Joshi, et al. · Biomedical Materials & Devices · 1
Delivery of gold nanoparticle-conjugated M2e influenza vaccine in mice using coated microneedles
2023 · Lazar D. Nesovic, Carsen J. Roach, et al. · Biomaterials Science · 22
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Peptide Cross-Linking Using Tyrosine Residues Facilitated by an Exogenous Nickel–Histidine Complex: A Facile Approach for Enhancing Vaccine-Specific Immunogenicity
2022 · Logan R. Wilks, Gaurav Joshi, et al. · ACS Infectious Diseases · 4
Drug-Coated Floss to Treat Gum Diseases: In Vitro and In Vivo Characterization
2022 · Seth Boese, Harvinder Singh Gill · ACS Applied Materials & Interfaces · 3
Tyrosine-Based Cross-Linking of Peptide Antigens to Generate Nanoclusters with Enhanced Immunogenicity: Demonstration Using the Conserved M2e Peptide of Influenza A
2021 · Logan R. Wilks, Gaurav Joshi, et al. · ACS Infectious Diseases · 9
M2e conjugated gold nanoparticle influenza vaccine displays thermal stability at elevated temperatures and confers protection to ferrets
2021 · Rohan S.J. Ingrole, Wenqian Tao, et al. · Vaccine · 33
Coated floss for drug delivery into the gum pocket
2021 · Seth Boese, Harvinder Singh Gill · International Journal of Pharmaceutics · 10
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