Award

R21 AI090501

Funder: National Institute of Allergy and Infectious Diseases

Funded outputs count: 24

Funder award ID: R21 AI090501

OpenAlex ID: G3335269064

Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases

2025 · Chiranjeevi Pasala, Chander S. Digwal, et al. · RSC Chemical Biology · 9

N‐Glycosylation‐Induced Pathologic Protein Conformations as a Tool to Guide the Selection of Biologically Active Small Molecules

2024 · Andrea Magni, Cristiano Sciva, et al. · Chemistry - A European Journal · 9

PDF

How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view

2023 · Matteo Castelli, Pengrong Yan, et al. · Structure · 34

Targeting stressor-induced dysfunctions in protein–protein interaction networks via epichaperomes

2022 · Stephen D. Ginsberg, Sahil Sharma, et al. · Trends in Pharmacological Sciences · 31

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone

2020 · Pengrong Yan, Hardik J. Patel, et al. · Cell Reports · 60

PDF

Chaperome heterogeneity and its implications for cancer study and treatment

2018 · Tai Wang, Anna Rodina, et al. · Journal of Biological Chemistry · 43

Adapting to stress — chaperome networks in cancer

2018 · Suhasini Joshi, Tai Wang, et al. · Nature reviews. Cancer · 148

The epichaperome is an integrated chaperome network that facilitates tumour survival

2016 · Anna Rodina, Tai Wang, et al. · Nature · 290

RNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures

2016 · Mayurbhai R. Patel, Stephen D. Kozuch, et al. · Nano Letters · 18

Editorial (Thematic Issue: Heat Shock Proteins in Disease - From Molecular Mechanisms to Therapeutics)

2016 · Gabriela Chiosis · Current Topics in Medicinal Chemistry · 9

Voices of chemical biology

2015 · Bertozzi, Carolyn R, Stockwell, Brent R, et al. · Nature Chemical Biology · 14

PDF

Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94

2015 · Hardik J. Patel, Pallav D. Patel, et al. · Journal of Medicinal Chemistry · 65

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis

2014 · Saleh Rachidi, Shaoli Sun, et al. · Journal of Hepatology · 65

Selective targeting of the stress chaperome as a therapeutic strategy

2014 · Tony Taldone, Stefan O. Ochiana, et al. · Trends in Pharmacological Sciences · 111

Protein chaperones: a composition of matter review (2008 – 2013)

2014 · Tony Taldone, Hardik J Patel, et al. · Expert Opinion on Therapeutic Patents · 31

Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein

2013 · Anna Rodina, Pallav D. Patel, et al. · Chemistry & Biology · 103

PDF

Molecular Chaperone gp96 Is a Novel Therapeutic Target of Multiple Myeloma

2013 · Yunpeng Hua, Shai White-Gilbertson, et al. · Clinical Cancer Research · 73

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

2013 · Pallav D Patel, Pengrong Yan, et al. · Nature Chemical Biology · 217

Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series

2013 · Tony Taldone, Pallav D. Patel, et al. · Journal of Medicinal Chemistry · 77

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes

2013 · Tony Taldone, Anna Rodina, et al. · Beilstein Journal of Organic Chemistry · 17

PDF

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

2011 · Komal Jhaveri, Tony Taldone, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 456

PDF

Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy

2011 · Tony Taldone, Erica M. Gomes-DaGama, et al. · Bioorganic & Medicinal Chemistry Letters · 24

Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment

2011 · Hardik J Patel, Shanu Modi, et al. · Expert Opinion on Drug Discovery · 101

Design, synthesis, and evaluation of small molecule Hsp90 probes

2011 · Tony Taldone, Danuta Zatorska, et al. · Bioorganic & Medicinal Chemistry · 51