Phenotype, dynamics and activation of myocardial B lymphocytes in response toischemia/reperfusion injury
Description: Project narrative Recent evidence suggests that myocardial B lymphocytes play a critical role in determining the balance between adaptive and maladaptive effects of the inflammatory response to cardiac damage, but our current knowledge of cardiac B cells is extremely limited. The overall goal of the studies outlined in this proposal is to systematically explore the biology of myocardial B lymphocytes in health and disease. The findings from this work will be instrumental for the development of innovative B cell focused therapies for the treatment of cardiovascular disease.
Funding type: career_development
Funder scheme: K08
Start date: 2019-08-01
End date: 2024-07-31
Investigator: LUIGI ADAMO
Institution: JOHNS HOPKINS UNIVERSITY
Funded outputs count: 21
Funder award ID: K08HL145108
OpenAlex ID: G3385640036