Get started
Award

Optimizing Antiretroviral Use in Aging: Pharmacokinetics, Response, and Toxicity

Description: NARRATIVE By 2015, more than 50% of the HIV-infected population in the United States will be at least 50 years of age, and little is known about the optimal clinical care of aging HIV-infected patients. The goal of this and subsequent research is to identify patient-specific factors modifying antiretroviral response and toxicity. This could lead to specific treatment recommendations for older HIV-infected patients.
Funding type: career_development
Funder scheme: K23
Start date: 2011-03-01
End date: 2017-02-28
Investigator: JULIE BRUMER DUMOND
Institution: UNIV OF NORTH CAROLINA CHAPEL HILL
Field: Medicine
Funded outputs count: 20
Funder award ID: K23AI093156
OpenAlex ID: G34429661
Differential Extracellular, but Similar Intracellular, Disposition of two Tenofovir Formulations in the Male Genital Tract
2018 · Julie B Dumond, Stephen A Greene, et al. · Antiviral Therapy · 8
PDF
Pharmacogenetic Analysis of the Model‐Based Pharmacokinetics of Five Anti‐HIV Drugs: How Does This Influence the Effect of Aging?
2017 · Jingxian Chen, Farida S. Akhtari, et al. · Clinical and Translational Science · 8
PDF
Comparison of tenofovir plasma and tissue exposure using a population pharmacokinetic model and bootstrap: a simulation study from observed data
2017 · Jon W. Collins, J. Heyward Hull, et al. · Journal of Pharmacokinetics and Pharmacodynamics · 5
Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection
2016 · Brian M. Maas, Owen Francis, et al. · PLoS ONE · 5
PDF
Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV‐Infected Subjects With Aging Biomarkers
2016 · JB Dumond, J Chen, et al. · CPT Pharmacometrics & Systems Pharmacology · 12
PDF
p16INK4a, a Senescence Marker, Influences Tenofovir/Emtricitabine Metabolite Disposition in HIV‐Infected Subjects
2016 · JB Dumond, JW Collins, et al. · CPT Pharmacometrics & Systems Pharmacology · 6
PDF
Model‐Based Analysis of Unbound Lopinavir Pharmacokinetics in HIV‐Infected Pregnant Women Supports Standard Dosing in the Third Trimester
2016 · J Chen, S Malone, et al. · CPT Pharmacometrics & Systems Pharmacology · 4
PDF
Pharmacokinetic Modeling of Lamivudine and Zidovudine Triphosphates Predicts Differential Pharmacokinetics in Seminal Mononuclear Cells and Peripheral Blood Mononuclear Cells
2015 · Julie B. Dumond, Kuo H. Yang, et al. · Antimicrobial Agents and Chemotherapy · 10
Brief Report
2015 · Julie B. Dumond, Joseph Rigdon, et al. · JAIDS Journal of Acquired Immune Deficiency Syndromes · 6
Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are associated with p16 INK4a Expression in Subjects on Combination Therapy
2015 · Julie B Dumond, Owen Francis, et al. · Antiviral Therapy · 5
Single and Multiple Dose Pharmacokinetics of Dolutegravir in the Genital Tract of HIV-Negative Women
2013 · Jessica L Adams, Kristine B Patterson, et al. · Antiviral Therapy · 39
Dolutegravir Pharmacokinetics in the Genital Tract and Colorectum of HIV-Negative Men After Single and Multiple Dosing
2013 · Benjamin N. Greener, Kristine B. Patterson, et al. · JAIDS Journal of Acquired Immune Deficiency Syndromes · 66
Pharmacokinetics of two common antiretroviral regimens in older HIV ‐infected patients: a pilot study
2013 · JB Dumond, JL Adams, et al. · HIV Medicine · 26
Protein Binding of Lopinavir and Ritonavir During 4 Phases of Pregnancy
2012 · Kristine B. Patterson, Julie B. Dumond, et al. · JAIDS Journal of Acquired Immune Deficiency Syndromes · 41
Raltegravir Pharmacokinetics in Treatment-Naive Patients Is Not Influenced by Race: Results from the Raltegravir Early Therapy in African-Americans Living with HIV (REAL) Study
2012 · David A. Wohl, Julie B. Dumond, et al. · Antimicrobial Agents and Chemotherapy · 16
Pharmacokinetic Modelling of Efavirenz, Atazanavir, Lamivudine and Tenofovir in the Female Genital Tract of HIV-Infected Pre-Menopausal Women
2012 · Julie B. Dumond, Melanie R. Nicol, et al. · Clinical Pharmacokinetics · 27
Effect of Anticholinergic Use for the Treatment of Overactive Bladder on Cognitive Function in Postmenopausal Women
2012 · Elizabeth J. Geller, Andrea K. Crane, et al. · Clinical Drug Investigation · 27
Modest but Variable Effect of Rifampin on Steady-State Plasma Pharmacokinetics of Efavirenz in Healthy African-American and Caucasian Volunteers
2011 · Awewura Kwara, Karen T. Tashima, et al. · Antimicrobial Agents and Chemotherapy · 24
Single and Multiple Dose Pharmacokinetics of Maraviroc in Saliva, Semen, and Rectal Tissue of Healthy HIV-Negative Men
2011 · Kevin C. Brown, Kristine B. Patterson, et al. · The Journal of Infectious Diseases · 85
PDF
Everyone Eats Bread: A Multicultural Unit for First Graders.
1993 · Betty J. Belanus, Catherine H. Kerst · 1
Year
Topic