Elucidation of the effects of anti-diabetes and anti-complications by activation of heat shock response pathway and translation for clinical application
Description: The heat shock response (HSR) is a highly conserved biological defense and adaptation system from bacteria to human beings that responds not only to temperature changes but also to external stresses such as virus infection, ultraviolet or radiation exposure. As a result, it produces the heat shock protein (HSP) and contributes to cell and organ protection. HSR decreases its activity in chronic inflammation and chronic high glucose in diabetes, and causes a decline in the biological function of maintaining normal glucose tolerance. On the other hand, activation of HSP by various methods shows anti-diabetic effects such as enhancement of insulin sensitivity, improvement of glucose tolerance, reduction of visceral fat, and improvement of fatty liver. In our study, we showed that reduction of HSP in the whole body causes diabetes, and restoration of HSP72 expression in liver specifically can improve almost all systemic abnormal glucose metabolism.
Amount: ¥16,640,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Eiichi Araki
Institution: Kumamoto University
Topic: Heat shock proteins research
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 32
Funder award ID: 17H04201
OpenAlex ID: G3443786474