A new approach to modeling ALS based on TBK1 mutation in mice
Description: PROJECT NARRATIVE ALS and FTD are neurodegenerative diseases that cause paralysis and dementia, respectively. Both diseases are progressive, which is unstoppable and invariably lead to death. The two are related diseases because the same gene mutations can cause either or both diseases. To accelerate understanding of these diseases, we propose a new approach to generate transgenic mouse models by delivering robust transgene expression in the spinal cord.
Funding type: research
Funder scheme: R21
Start date: 2016-07-01
End date: 2019-06-30
Investigator: ZUOSHANG XU
Institution: UNIV OF MASSACHUSETTS MED SCH WORCESTER
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 2
Funder award ID: R21NS098497
OpenAlex ID: G3444529892