Sirtuin -Dependent Regulation of Tuberculosis and HIV Interactions in Macrophages
Description: NARRATIVE Tuberculosis is the leading cause of death in mankind due to infections, and more than 8 million new cases occur each year with 1.2 million deaths per year. Coinfection with HIV-1 has rendered the control of tuberculosis very difficult, and we have discovered a new method of augmenting host defense so that both M. tuberculosis which causes tuberculosis and HIV-1 which causes AIDS can be controlled using a new class of Sirtuin-based drugs. We propose to develop a new intervention using immunotherapy to simultaneously control HIV-TB coinfections.
Funder: National Institutes of Health
Amount: $1,298,000
Funding type: research
Funder scheme: R01
Start date: 2024-08-01
End date: 2029-07-31
Investigator: JANICE J ENDSLEY
Institution: METHODIST HOSPITAL RESEARCH INSTITUTE
Funded outputs count: 9
Funder award ID: 1r01ai184551-01
OpenAlex ID: G3494166328