Get started
Award

Multiscale modeling of mechanisms for viral capsid assembly and polymorphism

Description: PUBLIC HEALTH RELEVANCE: Viral diseases and acquired drug resistance by viruses are major biomedical challenges. The most effective antiviral treatments fight acquired resistance by using use multiple drugs to target several steps in the infection process, but relatively few treatments target viral assembly. By identifying the features that make viral assembly successful, we can learn to block it and thereby create novel antivirus therapies.
Funding type: research
Funder scheme: R01
Start date: 2008-12-01
End date: 2013-11-30
Investigator: MICHAEL F HAGAN
Institution: BRANDEIS UNIVERSITY
Subfield: Ecology
Funded outputs count: 20
Funder award ID: R01AI080791
OpenAlex ID: G3540468389
Modeling Viral Capsid Assembly
2014 · Michael F. HAGAN · Advances in chemical physics · 181
Viral genome structures are optimal for capsid assembly
2013 · Jason D Perlmutter, Cong Qiao, et al. · eLife · 135
Simulations of HIV Capsid Protein Dimerization Reveal the Effect of Chemistry and Topography on the Mechanism of Hydrophobic Protein Association
2012 · Naiyin Yu, Michael F. Hagan · Biophysical Journal · 13
PDF
Mechanisms of Budding of Nanoscale Particles through Lipid Bilayers
2012 · Teresa Ruiz-Herrero, Enrique Velasco, et al. · The Journal of Physical Chemistry B · 54
Differential assembly of Hepatitis B Virus core protein on single- and double-stranded nucleic acid suggest the dsDNA-filled core is spring-loaded
2012 · Mary S. Dhason, Joseph C.-Y. Wang, et al. · Virology · 74
An Examination of the Electrostatic Interactions between the N-Terminal Tail of the Brome Mosaic Virus Coat Protein and Encapsidated RNAs
2012 · Peng Ni, Zhao Wang, et al. · Journal of Molecular Biology · 82
Sitting at the Edge: How Biomolecules use Hydrophobicity to Tune Their Interactions and Function
2012 · Amish J. Patel, Patrick Varilly, et al. · The Journal of Physical Chemistry B · 211
Self-assembly of 2D membranes from mixtures of hard rods and depleting polymers
2011 · Yasheng Yang, Edward Barry, et al. · Soft Matter · 51
Mechanisms of kinetic trapping in self-assembly and phase transformation
2011 · Michael F. Hagan, Oren M. Elrad, et al. · The Journal of Chemical Physics · 127
PDF
Excitable Patterns in Active Nematics
2011 · L. Giomi, L. Mahadevan, et al. · Physical Review Letters · 122
PDF
Prolonging assembly through dissociation: A self-assembly paradigm in microtubules
2011 · Sumedha, Michael F. Hagan, et al. · Physical Review E · 11
PDF
Encapsulation of a polymer by an icosahedral virus
2010 · Oren M Elrad, Michael F Hagan · Physical Biology · 121
PDF
Mechanisms of Capsid Assembly around a Polymer
2010 · Aleksandr Kivenson, Michael F. Hagan · Biophysical Journal · 57
PDF
Self-Limited Self-Assembly of Chiral Filaments
2010 · Yasheng Yang, Robert B. Meyer, et al. · Physical Review Letters · 57
PDF
Understanding the Concentration Dependence of Viral Capsid Assembly Kinetics—the Origin of the Lag Time and Identifying the Critical Nucleus Size
2010 · Michael F. Hagan, Oren M. Elrad · Biophysical Journal · 109
PDF
A theory for viral capsid assembly around electrostatic cores
2009 · Michael F. Hagan · The Journal of Chemical Physics · 70
PDF
The role of collective motion in examples of coarsening and self-assembly
2008 · Stephen Whitelam, Edward H. Feng, et al. · Soft Matter · 137
Mechanisms of Size Control and Polymorphism in Viral Capsid Assembly
2008 · Oren M. Elrad, Michael F. Hagan · Nano Letters · 93
Controlling viral capsid assembly with templating
2008 · Michael F. Hagan · Physical Review E · 66
A Protocol for Secure Communication and Its Performance.
1987 · David P. Anderson, Domenico Ferrari, et al. · International Conference on Distributed Computing Systems · 2
Year
Topic