Elucidation of the role of Wnt in tumor immunity of malignant glioma and its application to therapy
Description: We studied the relationship between intratumoral expression of Wnt and expression of PDL-1 and therapeutic effect, but the correlation between Wnt5a and PD-L1 expression in glioblastoma was weak, and the expression level of PD-L1 in patients with glioblastoma did not show the difference in survival time.In the analysis of Gene Expression Omnibus Database, there was PD-1 as a highly correlated gene candidate with Wnt-5a, but in vitro study the gene expression change related to immunosuppression of tumor cells by Wnt5a stimulation could not detected, and macrophage-mediated influence was no obvious in expression of immunity checkpoint-related genes.
Amount: ¥4,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2015-04-01
End date: 2018-03-31
Investigator: Hirofumi HIRANO (lead)
Institution: Kagoshima University
Funded outputs count: 9
Funder award ID: 15K10338
OpenAlex ID: G363242003