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Enoph1-adi1双重调控多胺和mt1-mmp促进缺血早期血脑屏障损伤的分子机制

Amount: ¥340,000
Funding type: grant
Funder scheme: 地区科学基金项目
Start date: 2017-01-01
End date: 2021-12-31
Investigator: 圆 张
Institution: 内蒙古科技大学包头医学院
Funded outputs count: 17
Funder award ID: 81760227
OpenAlex ID: G3757186972
MMP ‐2‐mediated Scube2 degradation promotes blood–brain barrier disruption by blocking the interaction between astrocytes and endothelial cells via inhibiting Sonic hedgehog pathway during early cerebral ischemia
2023 · Tengrui Shi, Shiqin Yue, et al. · Journal of Neurochemistry · 25
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Intranasal 15d-PGJ2 inhibits the growth of rat lactotroph pituitary neuroendocrine tumors by inducing PPARγ-dependent apoptotic and autophagic cell death
2023 · Zongyang Li, Lei Chen, et al. · Frontiers in Neuroscience · 5
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Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood–brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP
2023 · Dexin Yang, Li Su, et al. · Experimental Neurology · 9
Activation of Swell1 in microglia suppresses neuroinflammation and reduces brain damage in ischemic stroke
2022 · Baoyi Chen, Cong Xie, et al. · Neurobiology of Disease · 18
Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease
2022 · Xiangbao Meng, Yuan Zhang, et al. · Phytotherapy Research · 15
Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice
2022 · Zongyang Li, Xiangbao Meng, et al. · Alzheimer s Research & Therapy · 28
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Correction to “A Co-Doped Fe3O4 Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic Stroke”
2022 · Yunsheng Liu, Xiaojun Wang, et al. · ACS Applied Materials & Interfaces · 2
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Alterations of the Gut Microbiome in Patients With Pituitary Adenoma
2022 · Jinxian Hu, Jihu Yang, et al. · Pathology & Oncology Research · 20
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A novel natural PPARγ agonist, Gypenoside LXXV, ameliorates cognitive deficits by enhancing brain glucose uptake via the activation of Akt/GLUT4 signaling in db/db mice
2022 · Xiangbao Meng, Yuan Zhang, et al. · Phytotherapy Research · 18
A novel DPP ‐4 inhibitor Gramcyclin A attenuates cognitive deficits in APP / PS1 /tau triple transgenic mice via enhancing brain GLP ‐1‐dependent glucose uptake
2022 · Zongyang Li, Yuan Zhang, et al. · Phytotherapy Research · 20
A Linarin Derivative Protects against Ischemia‐Induced Neuronal Injury in Mice by Promoting Cerebral Blood Flow Recovery via KDELR‐Dependent CSPG4 Activation
2022 · Cong Xie, Shiqin Yue, et al. · Oxidative Medicine and Cellular Longevity · 10
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A Co-Doped Fe 3 O 4 Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic Stroke
2021 · Yunsheng Liu, Xiaojun Wang, et al. · ACS Applied Materials & Interfaces · 75
Combined Analysis of Surface Protein Profile and microRNA Expression Profile of Exosomes Derived from Brain Microvascular Endothelial Cells in Early Cerebral Ischemia
2021 · Dexin Yang, Zongyang Li, et al. · ACS Omega · 28
Intranasal 15d-PGJ2 ameliorates brain glucose hypometabolism via PPARγ-dependent activation of PGC-1α/GLUT4 signalling in APP/PS1 transgenic mice
2021 · Zongyang Li, Yuan Zhang, et al. · Neuropharmacology · 19
Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells
2020 · Shanshan Qiao, Dexin Yang, et al. · Life Sciences · 16
Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro
2020 · Yuan Zhang, Xiaofeng Li, et al. · Journal of Neurochemistry · 58
Enolase-phosphatase 1 as a novel potential malignant glioma indicator promotes cell proliferation and migration
2018 · Li Su, Ke Yang, et al. · Oncology Reports · 12
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