Strategies to control peri-implant bone resorption using a space-medical approach in a microgravity environment
Description: In this study, we focused on the role of Trpv4 as a mechano-sensor in osteocytes. We aimed to find the differentially expressed molecules in the 3D culture of IDG-SW3 osteocytes under microgravity and normal (1G) conditions. In the 3D culture under the microgravity environment, we found differences in the expression of several genes compared to that under the regular (1G) environment. In addition, since the relationship between osteocytes and HMGB-1 has been recently pointed out, we investigated the effect of HMGB-1 on bone regeneration using a rabbit mandible and found that the HMGB-1-treated group showed high bone regeneration ability with the migration of macrophages.
Amount: ¥17,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Ryuji Hosokawa (lead)
Institutions: Kyushu Dental University, Kyushu Dental College
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Funded outputs count: 10
Funder award ID: 18H02995
OpenAlex ID: G386367136