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Multimodal Mapping of Subcortical and Cortical Functional Network Disturbances in Focal Epilepsy

Description: Epilepsy is a common and devastating disorder that results in problems with alertness and cognition. This study will use functional magnetic resonance imaging as well as direct brain recordings in individuals with focal epilepsy to study how abnormal brain connections may affect various neural networks. Our goal is an improved understanding of brain network changes in focal epilepsy, which will lead to novel treatments to prevent the negative effects of this disorder.
Funding type: career_development
Funder scheme: K99
Start date: 2016-08-01
End date: 2017-07-31
Investigator: DARIO J ENGLOT
Institution: VANDERBILT UNIVERSITY MEDICAL CENTER
Funded outputs count: 16
Funder award ID: K99NS097618
OpenAlex ID: G3898438024
MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture
2021 · Victoria L. Morgan, Graham W. Johnson, et al. · Network Neuroscience · 17
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Structural Correlates of the Sensorimotor Cerebellum in Parkinson's Disease and Essential Tremor
2020 · Alexander M. Lopez, Paula Trujillo, et al. · Movement Disorders · 33
Thalamic arousal network disturbances in temporal lobe epilepsy and improvement after surgery
2019 · Hernán F J González, Srijata Chakravorti, et al. · Journal of Neurology Neurosurgery & Psychiatry · 51
Brainstem Functional Connectivity Disturbances in Epilepsy may Recover After Successful Surgery
2019 · Hernán F J González, Sarah E Goodale, et al. · Neurosurgery · 21
Relating structural and functional brainstem connectivity to disease measures in epilepsy
2018 · Dario J. Englot, Hernan F.J. Gonzalez, et al. · Neurology · 62
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Rates and predictors of success and failure in repeat epilepsy surgery: A meta‐analysis and systematic review
2017 · Max O. Krucoff, Alvin Y. Chan, et al. · Epilepsia · 98
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Functional connectivity disturbances of the ascending reticular activating system in temporal lobe epilepsy
2017 · Dario J Englot, Pierre-Francois D’Haese, et al. · Journal of Neurology Neurosurgery & Psychiatry · 79
Magnetic resonance imaging connectivity for the prediction of seizure outcome in temporal lobe epilepsy
2017 · Victoria L. Morgan, Dario J. Englot, et al. · Epilepsia · 77
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Multiple Subpial Transections for Medically Refractory Epilepsy: A Disaggregated Review of Patient-Level Data
2017 · John D Rolston, Hansen Deng, et al. · Neurosurgery · 30
Seizure Outcomes in Occipital Lobe and Posterior Quadrant Epilepsy Surgery: A Systematic Review and Meta-Analysis
2017 · Stephen C Harward, William C Chen, et al. · Neurosurgery · 51
Factors Associated With Pre- and Postoperative Seizures in 1033 Patients Undergoing Supratentorial Meningioma Resection
2017 · William C. Chen, Stephen T. Magill, et al. · Neurosurgery · 106
Quality-of-life metrics with vagus nerve stimulation for epilepsy from provider survey data
2016 · Dario J. Englot, Kevin H. Hassnain, et al. · Epilepsy & Behavior · 107
An unexpectedly high rate of revisions and removals in deep brain stimulation surgery: Analysis of multiple databases
2016 · John D. Rolston, Dario J. Englot, et al. · Parkinsonism & Related Disorders · 149
Continued medical management of drug‐resistant epilepsy: implications for surgical consideration
2016 · Dario J. Englot · Epilepsia · 1
Regional and global connectivity disturbances in focal epilepsy, related neurocognitive sequelae, and potential mechanistic underpinnings
2016 · Dario J. Englot, Peter E. Konrad, et al. · Epilepsia · 217
Rate and complications of adult epilepsy surgery in North America: Analysis of multiple databases
2016 · John D. Rolston, Dario J. Englot, et al. · Epilepsy Research · 48
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