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Biological Markers of Aflatoxin Exposure and Methylation

Description: Understanding the role of environmental factors in development of HCC will assist in the identification of high risk populations that could be targeted for screening or prevention strategies. The development of screening methods for the early detection of disease in high risk populations will lead to better treatment and survival.

Funder: National Institute of Environmental Health Sciences

Funding type: research

Funder scheme: R01

Start date: 1990-01-01

End date: 2015-12-31

Investigator: REGINA M SANTELLA

Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES

Topic: Mycotoxins in Agriculture and Food

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Funded outputs count: 84

Funder award ID: R01ES005116

OpenAlex ID: G3916197029

Environmental exposure and clinical correlates of hepatocellular carcinoma in New York City: a case only study

2021 · Hui-Chen Wu, Jing Shen, et al. · Cancer Causes & Control · 3

8-hydroxy-2'-deoxyguanosine, a major mutagenic oxidative DNA lesion, and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution

2020 · Wen-Wang, L, Rodriguez-Alcaraz, A, et al. · Carolina Digital Repository (University of North Carolina at Chapel Hill)

Aflatoxin B1 exposure increases the risk of hepatocellular carcinoma associated with hepatitis C virus infection or alcohol consumption

2018 · Yu-Ju Chu, Hwai-I Yang, et al. · European Journal of Cancer · 114

Plasma DNA methylation marker and hepatocellular carcinoma risk prediction model for the general population

2017 · Hui-Chen Wu, Hwai-I Yang, et al. · Carcinogenesis · 62

Global Level of Plasma DNA Methylation is Associated with Overall Survival in Patients with Hepatocellular Carcinoma

2017 · Chih-Ching Yeh, Abhishek Goyal, et al. · Annals of Surgical Oncology · 20

Aflatoxin B1 exposure increases the risk of cirrhosis and hepatocellular carcinoma in chronic hepatitis B virus carriers

2017 · Yu‐Ju Chu, Hwai‐I Yang, et al. · International Journal of Cancer · 106

Telomere Length and Risk of Hepatocellular Carcinoma: A Nested Case–Control Study in Taiwan Cancer Screening Program Cohort

2017 · HUI ZENG, HUI-CHEN WU, et al. · Anticancer Research · 14

Evaluating normalization approaches for the better identification of aberrant microRNAs associated with hepatocellular carcinoma

2016 · Jing Shen, Qiao Wang, et al. · Hepatoma Research · 15

Plasma Adiponectin and Hepatocellular Carcinoma Survival Among Patients Without Liver Transplantation

2016 · JING SHEN, CHIH-CHING YEH, et al. · Anticancer Research · 18

NEpiC: a network-assisted algorithm for epigenetic studies using mean and variance combined signals

2016 · Peifeng Ruan, Jing Shen, et al. · Nucleic Acids Research · 15

Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies

2016 · Jing Shen, Abby B. Siegel, et al. · Hepatoma Research · 14

Blood DNA methylation markers in prospectively identified hepatocellular carcinoma cases and controls from Taiwan

2016 · Hui-Chen Wu · World Journal of Hepatology · 8

Exploration of Deregulated Long Non-Coding RNAs in Association with Hepatocarcinogenesis and Survival

2015 · Jing Shen, Abby Siegel, et al. · Cancers · 16

Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas

2015 · Jing Shen, Clare LeFave, et al. · BMC Medical Genomics · 31

Genome-Wide Expression of MicroRNAs Is Regulated by DNA Methylation in Hepatocarcinogenesis

2015 · Jing Shen, Shuang Wang, et al. · Gastroenterology Research and Practice · 22

The p53 mutation spectrum in hepatocellular carcinoma from Guangxi, China : role of chronic hepatitis B virus infection and aflatoxin B1 exposure

2014 · Lu‐Nan Qi, Tao Bai, et al. · Liver International · 100

Genome-Wide and Differential Proteomic Analysis of Hepatitis B Virus and Aflatoxin B1 Related Hepatocellular Carcinoma in Guangxi, China

2013 · Lu-Nan Qi, Le-Qun Li, et al. · PLoS ONE · 42

Environmental Exposures and Hepatocellular Carcinoma

2013 · Regina M Santella, Hui-Chen Wu · Journal of Clinical and Translational Hepatology · 22

Exploration of Genome-Wide Circulating MicroRNA in Hepatocellular Carcinoma: MiR-483-5p as a Potential Biomarker

2013 · Jing Shen, Antai Wang, et al. · Cancer Epidemiology Biomarkers & Prevention · 101

Global DNA methylation in a population with aflatoxin B 1 exposure

2013 · Hui-Chen Wu, Qiao Wang, et al. · Epigenetics · 42

Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis

2013 · Emanuele D’Amico, Pam Factor-Litvak, et al. · Free Radical Biology and Medicine · 321

Network‐based regularization for matched case‐control analysis of high‐dimensional DNA methylation data

2012 · Hokeun Sun, Shuang Wang · Statistics in Medicine · 37

Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips

2012 · Jing Shen, Shuang Wang, et al. · Epigenetics · 157

The Role of Aflatoxins in Hepatocellular Carcinoma

2012 · Hui-Chen Wu, Regina Santella · Hepatitis Monthly · 135

Genome-wide aberrant DNA methylation of microRNA host genes in hepatocellular carcinoma

2012 · Jing Shen, Shuang Wang, et al. · Epigenetics · 60