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Epigenetic Mechanisms of Neurodevelopment in Prenatal Alcohol Exposure

Description: PROJECT NARRATIVE Prenatal alcohol exposure (PAE) is a leading cause of preventable neurodevelopmental disability, and one contributory mechanism is impaired corticogenesis caused by alcohol’s suppression of neural progenitor cell (NPC) proliferation. This project investigates molecular mechanisms that contribute to this impaired proliferation, and tests the ability of prenatal choline supplementation to prevent these changes. Study outcomes will clarify the mechanistic action of choline in improving neurodevelopmental outcomes in PAE, and thus inform choline intervention strategies.

Funder: National Institutes of Health

Amount: $59,160

Funding type: fellowship

Funder scheme: F32

Start date: 2021-06-02

End date: 2022-03-14

Investigator: OLIVIA C RIVERA

Institution: UNIV OF NORTH CAROLINA CHAPEL HILL

Topic: Prenatal Substance Exposure Effects

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences