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Developing Pet Agents for Imaging Phosphodiesterase 10a (pde10a)

Description: PUBLIC HEALTH RELEVANCE: Huntington's disease is a progressive neurological disorder of motor, cognitive, and psychiatric disturbances. It was reported more than 15,000 Americans have HD. At least other 150,000 have a 50% risk of developing the disease and thousands more of their relatives live with the possibility that they might develop HD. A PET radiotracer of PDE10A may help physician to quantify the progression of Huntington Disease based on the PET measurement of PDE10A level in patients with the Huntington disease patients.
Funding type: research
Funder scheme: R33
Start date: 2011-02-01
End date: 2018-01-31
Investigator: ZHUDE TU
Institution: WASHINGTON UNIVERSITY
Funded outputs count: 54
Funder award ID: R33MH092797
OpenAlex ID: G4009729327
Absolute configuration and an improved automated cGMP production of a clinically promising radiotracer for imaging VAChT
2025 · Yanbo Yu, Anil Kumar Soda, et al. · Journal of Fluorine Chemistry
Design and Synthesis of Novel PET Radiotracers for Imaging Sphingosine-1-Phosphate Receptor 5 (S1PR5) in the Brain
2025 · Jiawen Lang, Wenjuan Zhou, et al. · Journal of Medicinal Chemistry · 1
Radiation dosimetry of [11C]TZ1964B as determined by whole-body PET imaging of nonhuman primates
2025 · Baijayanta Maiti, Noah L. Goldman, et al. · EJNMMI Research
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Synthesis and in vivo biological characterization of six carbon-11 sigma-1 receptor radiotracers in rodent and nonhuman primate
2025 · Anil Kumar Soda, Tianyu Huang, et al. · Bioorganic & Medicinal Chemistry · 2
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Synthesis and in vitro evaluation of novel compounds and discovery of a promising iodine-125 radioligand for purinergic P2X7 receptor (P2X7R)
2024 · Lin Qiu, Jinzhi Wang, et al. · Bioorganic & Medicinal Chemistry · 6
Two F-18 radiochemistry methods to synthesize a promising transient receptor potential canonical 5 (TRPC5) radioligand
2024 · Yanbo Yu, Sandip B. Jadhav, et al. · Journal of Fluorine Chemistry · 1
Metabolite Study and Structural Authentication for the First-in-Human Use Sphingosine-1-phosphate Receptor 1 Radiotracer
2024 · Lin Qiu, Hao Jiang, et al. · ACS Chemical Neuroscience · 5
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Synthesis and Characterization of a Specific Iodine‐125‐Labeled TRPC5 Radioligand
2020 · Yanbo Yu, Qianwa Liang, et al. · ChemMedChem · 2
In vivo Characterization of Four 18F-Labeled S1PR1 Tracers for Neuroinflammation
2020 · Hui Liu, Zonghua Luo, et al. · Molecular Imaging and Biology · 24
The impact of dopamine D2-like agonist/antagonist on [18F]VAT PET measurement of VAChT in the brain of nonhuman primates
2019 · Hui Liu, Zonghua Luo, et al. · European Journal of Pharmaceutical Sciences · 4
Design, synthesis, and in vitro bioactivity evaluation of fluorine-containing analogues for sphingosine-1-phosphate 2 receptor
2019 · Zonghua Luo, Hui Liu, et al. · Bioorganic & Medicinal Chemistry · 13
Radiosynthesis and evaluation of a fluorine-18 labeled radioligand targeting vesicular acetylcholine transporter
2018 · Xuyi Yue, Zonghua Luo, et al. · Bioorganic & Medicinal Chemistry Letters · 3
Exploration of Sulfur‐Containing Analogues for Imaging Vesicular Acetylcholine Transporter in the Brain
2018 · Zonghua Luo, Hui Liu, et al. · ChemMedChem · 5
Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents
2018 · Zonghua Luo, Adam J. Rosenberg, et al. · European Journal of Medicinal Chemistry · 24
Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation
2018 · Xuyi Yue, Dhruva D. Dhavale, et al. · Bioorganic & Medicinal Chemistry Letters · 18
Cholinergic imbalance in lumbar spinal cord of a rat model of multiple sclerosis
2018 · Chunling Liu, Hui Liu, et al. · Journal of Neuroimmunology · 3
In Vivo Characterization of Two 18F-Labeled PDE10A PET Radioligands in Nonhuman Primate Brains
2018 · Hui Liu, Hongjun Jin, et al. · ACS Chemical Neuroscience · 9
Kinetic modeling of [18F]V AT , a novel radioligand for positron emission tomography imaging vesicular acetylcholine transporter in non‐human primate brain
2018 · Hongjun Jin, Xuyi Yue, et al. · Journal of Neurochemistry · 27
Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates
2018 · Zonghua Luo, Junbin Han, et al. · Organic & Biomolecular Chemistry · 17
Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands
2017 · Zonghua Luo, Xuyi Yue, et al. · Bioorganic & Medicinal Chemistry Letters · 16
Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease
2017 · Hongjun Jin, Junbin Han, et al. · European Journal of Pharmacology · 52
Upregulated Sphingosine 1-Phosphate Receptor 1 Expression in Human and Murine Atherosclerotic Plaques
2017 · Hui Liu, Hongjun Jin, et al. · Molecular Imaging and Biology · 22
Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response
2017 · Junbin Han, Hui Liu, et al. · Nuclear Medicine Communications · 67
Chiral resolution of serial potent and selective σ1 ligands and biological evaluation of (−)-[18F]TZ3108 in rodent and the nonhuman primate brain
2017 · Xuyi Yue, Hongjun Jin, et al. · Bioorganic & Medicinal Chemistry · 7
PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury
2017 · Hui Liu, Hongjun Jin, et al. · Molecular Imaging · 28
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