Cancer cell adaptation to metabolic stress
Description: PUBLIC HEALTH RELEVANCE: Overall Project Narrative Cancer cells exhibit altered metabolic regulation, which renders them preferentially vulnerable to serum and oxygen deprivation, conditions which arise in solid tumors. Recently, we demonstrated that cancer cells require unsaturated lipids to survive under these conditions, suggesting a novel therapeutic target for cancer treatment. This proposal investigates the role of unsaturated lipids in cancer cell metabolism and survival, and how this influences stress responses with the endoplasmic reticulum.
Funder: National Cancer Institute
Funding type: program
Funder scheme: P01
Start date: 2003-12-01
End date: 2021-08-31
Investigator: M. CELESTE SIMON
Institution: UNIVERSITY OF PENNSYLVANIA
Subfield: Cancer Research
Domain: Life Sciences
Funded outputs count: 143
Funder award ID: P01CA104838
OpenAlex ID: G4273772634