Fine-mapping of 8q24 and Loci Identified in Genome-Wide Studies for Breast & Colo
Description: PUBLIC HEALTH RELEVANCE: The goal of this project is to identify common risk alleles for breast and colorectal cancer in African American, Japanese American, Native Hawaiian, Latino and European American populations in the prospective Multiethnic Cohort Study. More specifically, we propose to fine-map genetic variation at chromosome 8q24 as well as regions identified in genome-wide scans in European Whites, in multiethnic samples, to localize functional variants as well as reveal the full spectrum of common alleles that contribute to risk of breast and colorectal cancer in the general population. We will also incorporate environment and lifestyle risk factors in association testing to assist in resolving potential heterogeneous genetic effects across populations, and, better define the subgroups of the population at greatest risk of developing these common cancers. We expect findings from this work to guide the development of future preventive, early detection and prognostic strategies.
Funder: National Institutes of Health
Amount: $637,200
Funding type: research
Funder scheme: R01
Start date: 2008-03-15
End date: 2012-02-28
Investigator: CHRISTOPHER ALAN HAIMAN
Institution: UNIVERSITY OF SOUTHERN CALIFORNIA
Subfield: Genetics
Domain: Life Sciences
Funded outputs count: 83
Funder award ID: 5r01ca132839-03
OpenAlex ID: G4276576992