Award

The Elongation Hypothesis of Autism

Description: Our pioneering research will identify genetic and environmental factors that regulate the expression of numerous ASD genes. Our research has the potential to diagnose and treat some forms of ASD, and possibly help reverse the ASD epidemic that now affects 1 out of every 88 children.

Funder: National Institute of Environmental Health Sciences

Funding type: grant

Funder scheme: DP1

Start date: 2013-09-30

End date: 2019-01-31

Investigator: MARK J. ZYLKA

Institution: UNIV OF NORTH CAROLINA CHAPEL HILL

Topic: Autism Spectrum Disorder Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Funded outputs count: 22

Funder award ID: DP1ES024088

OpenAlex ID: G4420028864

Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

2020 · Jessica A. Jiménez, Travis S. Ptacek, et al. · Molecular Autism · 36

Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

2020 · Giulia Fragola, Angela M. Mabb, et al. · Nature Communications · 40

lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA

2019 · Megan D. Schertzer, Keean C.A. Braceros, et al. · Molecular Cell · 127

High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq

2019 · Jeremy M. Simon, Smita R. Paranjape, et al. · Scientific Reports · 24

Single-cell transcriptomic analysis of mouse neocortical development

2019 · Lipin Loo, Jeremy M. Simon, et al. · Nature Communications · 277

Choice of vehicle affects pyraclostrobin toxicity in mice

2018 · Alexander H. Tuttle, Gabriela Salazar, et al. · Chemosphere · 37

A deep neural network to assess spontaneous pain from mouse facial expressions

2018 · Alexander H Tuttle, Mark J Molinaro, et al. · Molecular Pain · 158

Enhanced Nociception in Angelman Syndrome Model Mice

2017 · Eric S. McCoy, Bonnie Taylor-Blake, et al. · Journal of Neuroscience · 17

Toward a conceptual framework for early brain and behavior development in autism

2017 · J Piven, J T Elison, et al. · Molecular Psychiatry · 163

The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome

2017 · Jason J. Yi, Smita R. Paranjape, et al. · Journal of Biological Chemistry · 71

The Troubled Touch of Autism

2016 · Alexander H. Tuttle, Victoria B. Bartsch, et al. · Cell · 6

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms

2016 · Angela M. Mabb, Jeremy M. Simon, et al. · PLoS ONE · 50

Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration

2016 · Brandon L. Pearson, Jeremy M. Simon, et al. · Nature Communications · 128

Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact

2015 · J. Christopher Ehlen, Kelly A. Jones, et al. · Journal of Neuroscience · 91

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A

2015 · Jason J. Yi, Janet Berrios, et al. · Cell · 175

Gene Length Matters in Neurons

2015 · Mark J. Zylka, Jeremy M. Simon, et al. · Neuron · 144

Topoisomerase 1 inhibition reversibly impairs synaptic function

2014 · Angela M. Mabb, Paul H. M. Kullmann, et al. · Proceedings of the National Academy of Sciences · 49

Zylka et al. reply

2014 · Mark J. Zylka, Ben D. Philpot, et al. · Nature · 1