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In situ analysis of functional endocrine, vascular, and immune cell interactions during early postnatal development of the human pancreas

Description: The proposed work will use living pancreas slices obtained from juvenile human donors to investigate the structural and functional changes of the pancreatic islet during the first decade of life. The anticipated results could reveal developmental processes that diminish the islet’s natural defenses and trigger abnormal responses from local immune cells. Knowing these processes is crucial to propose intervention targets aimed at preventing the development of type 1 diabetes.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2018-09-25
End date: 2023-06-30
Investigator: MARCELA BRISSOVA
Institution: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
Subfield: Surgery
Field: Medicine
Funded outputs count: 34
Funder award ID: U01DK120456
OpenAlex ID: G4450030438
Paracrine inhibition via G protein inwardly rectifying potassium channels regulates glucagon secretion from human pancreatic alpha cells
2026 · Julia K. Panzer, Anna L. Lang, et al. · Cell Reports · 3
Activating Muscarinic Receptor Signaling in Intrapancreatic Neurons Is Required for Parasympathetic Cholinergic Control of Pancreatic Cell Function
2026 · Alejandro Caicedo, Noah Levi, et al. · Diabetes · 1
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NRF2 is required for neonatal mouse beta cell growth by maintaining redox balance and promoting mitochondrial biogenesis and function
2024 · Sharon Baumel-Alterzon, Liora S. Katz, et al. · Diabetologia · 18
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Genetic risk converges on regulatory networks mediating early type 2 diabetes
2023 · John T. Walker, Diane C. Saunders, et al. · Nature · 85
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An Intraislet Paracrine Signaling Pathway That Enables Glucagon to Stimulate Pancreatic β-Cells
2023 · Alejandro Caicedo, Mark O. Huising, et al. · Diabetes · 6
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Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles
2023 · Tiffany M. Richardson, Yasminye D. Pettway, et al. · Journal of Visualized Experiments
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A bright future for glucagon and alpha cell biology
2023 · Julia K Panzer, Alejandro Caicedo · Journal of Endocrinology · 4
Exocrine Pancreas in Type 1 and Type 2 Diabetes: Different Patterns of Fibrosis, Metaplasia, Angiopathy, and Adiposity
2023 · Jordan J. Wright, Adel Eskaros, et al. · Diabetes · 37
Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity
2023 · Jeeyeon Cha, Xin Tong, et al. · JCI Insight · 12
Protocol to generate and utilize pancreatic tissue slices to study endocrine and exocrine physiology in situ from mouse and human tissue
2023 · Julia K. Panzer, Alejandro Caicedo · STAR Protocols · 20
A Defect in Mitochondrial Complex III but Not in Complexes I or IV Causes Early β-Cell Dysfunction and Hyperglycemia in Mice
2023 · Anna L. Lang, Nadee Nissanka, et al. · Diabetes · 21
Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433–448
2023 · Teresa L. Mastracci, Minoti Apte, et al. · Diabetes · 1
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The human α cell in health and disease
2023 · Yasminye D Pettway, Diane C Saunders, et al. · Journal of Endocrinology · 20
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Immunotherapy With Low-Dose IL-2/CD25 Prevents β-Cell Dysfunction and Dysglycemia in Prediabetic NOD Mice
2023 · Farhan M. Qureshi, Julia K. Panzer, et al. · Diabetes · 12
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
2023 · Teresa L. Mastracci, Minoti Apte, et al. · Diabetes · 15
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Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
2023 · Tiffany M. Richardson, Diane C. Saunders, et al. · American Journal of Physiology-Endocrinology and Metabolism · 16
Restoring glutamate receptor signaling in pancreatic alpha cells rescues glucagon responses in type 1 diabetes
2022 · Julia K. Panzer, Alejandro Tamayo, et al. · Cell Reports · 29
Targeting the Pancreatic α-Cell to Prevent Hypoglycemia in Type 1 Diabetes
2021 · Julia K. Panzer, Alejandro Caicedo · Diabetes · 20
Microvessels enhance vascularization and function of transplanted insulin-producing cells
2021 · Alvin C. Powers, Marcela Brissova · Cell Metabolism · 4
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Integrated Analysis of the Pancreas and Islets Reveals Unexpected Findings in Human Male With Type 1 Diabetes
2021 · Rachana Haliyur, John T Walker, et al. · Journal of the Endocrine Society · 2
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Combinatorial transcription factor profiles predict mature and functional human islet α and β cells
2021 · Shristi Shrestha, Diane C. Saunders, et al. · JCI Insight · 45
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Optical Imaging of Pancreatic Innervation
2021 · Madina Makhmutova, Alejandro Caicedo · Frontiers in Endocrinology · 34
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The Human Islet: Mini-Organ With Mega-Impact
2021 · John T Walker, Diane C Saunders, et al. · Endocrine Reviews · 80
Deciphering the Complex Communication Networks That Orchestrate Pancreatic Islet Function
2020 · Jonathan Weitz, Danusa Menegaz, et al. · Diabetes · 37
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Pancreatic β-Cells Communicate With Vagal Sensory Neurons
2020 · Madina Makhmutova, Jonathan Weitz, et al. · Gastroenterology · 93
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