Regulation of RNA metabolism and cell growth control by SR protein kinases
Description: Project Narrative This grant will focus on SR protein-specific kinases (SRPKs) in transducing cellular signaling to the nucleus to regulate alternative pre-mRNA splicing. Given our recent discoveries that SRPKs are responsible for growth signal-regulated splicing and aberrant SRPK expression is linked to diverse cancers in humans, we propose to attack a series of fundamental questions in cancer etiology and progression, which is highly relevant to the general mission of NIH.
Funding type: research
Funder scheme: R01
Start date: 1996-05-01
End date: 2020-10-31
Investigator: STEVEN F DOWDY
Institution: UNIVERSITY OF CALIFORNIA, SAN DIEGO
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 69
Funder award ID: R01GM052872
OpenAlex ID: G4570814482