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U24 GM129539

Funder: Common Fund
Funded outputs count: 147
Funder award ID: U24 GM129539
OpenAlex ID: G4582736256
Structural basis for Mg²⁺–glycine synergy in the tandem glycine riboswitch revealed by cryo-EM
2026 · Nathan Jespersen, Jigneshkumar Dahyabhai Prajapati, et al. · npj Structural Biology
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The DNMT1 CXXC domain senses CpG islands for DNA methylation inhibition
2026 · Jian Fang, Bo Pan, et al. · Nature Communications
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Structural mechanisms for ATP-mediated inhibition of human NLRP6 inflammasome
2026 · Zhen Cui, Qingyu Sheng, et al. · Nature Structural & Molecular Biology
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Tuning of AMPA receptor activation by inhibitory auxiliary subunits and epilepsy-associated disease mutations
2026 · Thomas P. Newton, Maria V. Yelshanskaya, et al. · Nature Communications
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Multidomain interaction governs the filamentous assembly of the dominant-negative DNMT3A R882H mutant
2026 · Jianbin Chen, Jiuwei Lu, et al. · Proceedings of the National Academy of Sciences
Recovery of a minor cryo-EM particle population reveals conformational equilibria linking cofactor loading, turnover, and reactivation in methionine synthase
2026 · Haoyue Wang, Maxwell B. Watkins, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Structural insights enable drug discovery for the neuronal NBCn2 carbonate transporter
2026 · Shifan Yang, Yihan Zhao, et al. · Nature Communications
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Humans and rhesus macaques share maturation pathways of HIV-1 envelope-reactive V3-glycan bnAb lineages
2026 · Matthew Clark, Hui Li, et al. · Science Translational Medicine · 2
Structural insights into allosteric regulation of GdpP: A conformationally dynamic phosphodiesterase
2026 · Shadikejiang Shataer, Shannon Modla, et al. · Structure
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Structural and dynamic studies uncover a distinct allosteric modulatory site at the µ-opioid receptor
2026 · Haonan Zhang, Kirill Konovalov, et al. · Nature Communications · 1
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Structural and biochemical characterization of a novel inhibitor of NMNAT1, the gatekeeper of nuclear NAD + biosynthesis
2026 · Carisse Lansiquot, Ruoxi Wu, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Structural insights into the mechanism underpinning iron piracy in pathogenic Neisseria
2026 · Shubham Dubey, Julie Stoudenmire, et al. · Science Advances
Amyloid fibril polymorphism in the heart and liver of a patient with polyneuropathic ATTRv-V122Δ amyloidosis
2026 · Yasmin Ahmed, Binh An Nguyen, et al. · Communications Biology · 1
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Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI
2026 · Mohamed I. Barmada, Erin N. McGinity, et al. · Proceedings of the National Academy of Sciences · 1
Cryo-EM structures of UBA6 reveal mechanisms of E1–E2 specificity and dual FAT10/ubiquitin thioester transfer
2026 · Digant Nayak, Lijia Jia, et al. · Nature Communications · 1
Myosin Filaments of Vertebrate Skeletal and Cardiac Muscle are Highly Similar, but not Identical
2026 · Pouria Gholami Tilko, Hosna Rastegarpouyani, et al. · bioRxiv (Cold Spring Harbor Laboratory)
PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation
2026 · Aleksandr Sverzhinsky, Huijun Xue, et al. · Nature Communications · 3
Supercoiled DNA recognition and cleavage control in topoisomerase VI
2026 · Daniel E. Richman, Timothy J. Wendorff, et al. · Nature Communications · 2
Bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activation
2026 · Chhandosee Ganguly, Swarmistha Devi Aribam, et al. · Nature Communications · 5
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Structural characterization of a minimal KLC2/Nup358/BicD2 complex
2026 · Crystal R Noell, Sozanne R Solmaz · bioRxiv (Cold Spring Harbor Laboratory)
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A methylome-derived m 6 -dAMP trigger assembles a PUA-Cal-HAD immune filament that depletes dNTPs to abort phage infection
2026 · Zhiying Zhang, Yi Wu, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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The Structural Basis of alpha/beta-tubulin Assembly and Disassembly by Tubulin Cofactors
2025 · Aryan Taheri, Md Ashaduzzaman, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Simultaneous occupancy of Cu C and Cu D in the ammonia monooxygenase active site
2025 · Frank J. Tucci, Madeline B. Ho, et al. · Chemical Science · 8
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The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity
2025 · Tania Valencia, Laura Y. Yen, et al. · Nature Communications · 4
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Membrane‐forming phospholipids allosterically modulate native‐state prolyl isomerization in a CNG channel
2025 · Ashley J. Newton, Robert D. Latvala, et al. · Protein Science · 1
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