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A biomarker panel based smart mini-array system for the homecare of autoimmune kidney diseases

Description: Project Narrative We are aiming at building a urinary Biomarker Mini-Array (BMA) for an autoimmune kidney disease lupus nephritis, and a smartphone-based analysis/reporting system (SBARS) to process the BMA data, in order to monitor lupus flare in real-time at-home without the need of touching the kidney.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 2019-04-01

End date: 2026-01-31

Investigator: TIANFU WU

Institution: UNIVERSITY OF HOUSTON

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 16

Funder award ID: R01AG062987

OpenAlex ID: G46354013

Serum cell adhesion molecules (CAMs) NrCAM and P-Cadherin as novel biomarkers in lupus nephritis

2026 · Aygun Teymur, Ramesh Saxena, et al. · Lupus

Immunomodulation of behavior impairment via spleen-specific targeting lipid nanoparticles in a MeCP2 transgenic mouse model

2025 · Shu Zhang, Yaxi Li, et al. · Scientific Reports · 3

A serum biomarker panel and miniarray detection system for tracking disease activity and flare risk in lupus nephritis

2025 · Chenling Tang, Gongjun Tan, et al. · Frontiers in Immunology · 3

Urinary V‐Set Ig Domain‐Containing Protein 4 and Immune Complexes for Tracking Lupus Nephritis and Renal Pathology

2025 · Aygun Teymur, Chenling Tang, et al. · ACR Open Rheumatology · 2

Portable Fluorescence Microarray Reader-Enabled Biomarker Panel Detection System for Point-of-Care Diagnosis of Lupus Nephritis

2025 · Aygun Teymur, Iftak Hussain, et al. · Micromachines · 2

iPlexD2Go Integrates AI-Guided Biomarker Panel Discovery with Decentralized Multiplex Diagnostics

2025 · Zuan-Tao Lin, Chenling Tang, et al. · medRxiv

Urinary Immune Complexes Reflect Renal Pathology in Lupus Nephritis

2024 · Chenling Tang, Aygun Teymur, et al. · Diagnostics · 3

Advancing Point-of-Care Diagnosis: Digitalizing Combinatorial Biomarker Signals for Lupus Nephritis

2024 · Jiechang Guo, Aygun Teymur, et al. · Biosensors · 5

Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL/6 background

2024 · Yaxi Li, Shu Zhang, et al. · Frontiers in Immunology · 5

Proximity extension assay proteomics and renal single cell transcriptomics uncover novel urinary biomarkers for active lupus nephritis

2024 · Yaxi Li, Chenling Tang, et al. · Journal of Autoimmunity · 22

V‐Set Immunoglobulin Domain–Containing Protein 4 as a Novel Serum Biomarker of Lupus Nephritis and Renal Pathology Activity

2023 · Chenling Tang, Shu Zhang, et al. · Arthritis & Rheumatology · 16

Smartphone-Based Quantitative Analysis of Protein Array Signals for Biomarker Detection in Lupus

2022 · Guang Yang, Yaxi Li, et al. · Chemosensors · 2

Discovery of Novel Circulating Immune Complexes in Lupus Nephritis Using Immunoproteomics

2022 · Chenling Tang, Min Fang, et al. · Frontiers in Immunology · 20

Identification of polo‐like kinase 1 as a therapeutic target in murine lupus

2022 · Yaxi Li, Hongting Wang, et al. · Clinical & Translational Immunology · 8

Early Warning Diagnostics for Emerging Infectious Diseases in Developing into Late-Stage Pandemics

2021 · Taylor M. Oeschger, Duncan S. McCloskey, et al. · Accounts of Chemical Research · 50

Thermosensitive and Conductive Hybrid Polymer for Real-Time Monitoring of Spheroid Growth and Drug Responses

2021 · Zuan-Tao Lin, Jianhua Gu, et al. · ACS Sensors · 5