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Influenza vaccines inducing broadly cross protective immunity

Description: PROJECT NARRATIVE Development of an improved influenza vaccine inducing enhanced protection against a broader range of variant viruses will have a significant impact on public health. Novel approaches to improve the intrinsic cross protective property of currently licensed seasonal influenza vaccine platforms are expected to be applicable to clinic, resulting in high impacts on translating cross protective vaccines to humans.
Funding type: research
Funder scheme: R01
Start date: 2011-05-01
End date: 2023-06-30
Investigator: SANG-MOO KANG
Institution: GEORGIA STATE UNIVERSITY
Subfield: Epidemiology
Field: Medicine
Funded outputs count: 140
Funder award ID: R01AI093772
OpenAlex ID: G463578392
Heterologous Prime-Boost Vaccination with Inactivated Influenza Viruses Induces More Effective Cross-Protection than Homologous Repeat Vaccination
2023 · Noopur Bhatnagar, Ki-Hye Kim, et al. · Vaccines · 11
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Effective adjuvantation of nanograms of influenza vaccine and induction of cross-protective immunity by physical radiofrequency adjuvant
2022 · Zhuofan Li, Xinliang Kang, et al. · Scientific Reports · 9
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Enhanced Immunogenicity of an Influenza Ectodomain Matrix-2 Protein Virus-like Particle (M2e VLP) Using Polymeric Microparticles for Vaccine Delivery
2022 · Keegan Braz Gomes, Ipshita Menon, et al. · Viruses · 16
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Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle
2022 · Ki-Hye Kim, Zhuo Li, et al. · PLoS Pathogens · 37
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Adjuvant Effects of a New Saponin Analog VSA-1 on Enhancing Homologous and Heterosubtypic Protection by Influenza Virus Vaccination
2022 · Noopur Bhatnagar, Ki-Hye Kim, et al. · Vaccines · 10
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Vaccines against SARS-CoV-2 variants and future pandemics
2022 · Taeyoung Park, Hyogyeong Hwang, et al. · Expert Review of Vaccines · 25
Impact of hemagglutination activity and M2e immunity on conferring protection against influenza viruses
2022 · Judy Oh, Jeeva Subbiah, et al. · Virology · 4
A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine
2022 · Jeeva Subbiah, Judy Oh, et al. · npj Vaccines · 33
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Influenza Virus-like Particle-Based Hybrid Vaccine Containing RBD Induces Immunity against Influenza and SARS-CoV-2 Viruses
2022 · Ramireddy Bommireddy, Shannon Stone, et al. · Vaccines · 24
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Thermostable H1 hemagglutinin stem with M2e epitopes provides broad cross-protection against group1 and 2 influenza A viruses
2022 · Jeeva Subbbiah, Judy Oh, et al. · Molecular Therapy — Methods & Clinical Development · 6
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Low-Dose Cadmium Potentiates Metabolic Reprogramming Following Early-Life Respiratory Syncytial Virus Infection
2022 · Zachery R Jarrell, Matthew Ryan Smith, et al. · Toxicological Sciences · 16
Physical radiofrequency adjuvant enhances immune responses to influenza H5N1 vaccination
2022 · Zhuofan Li, Ki‐Hye Kim, et al. · The FASEB Journal · 8
Comparison of the effects of different potent adjuvants on enhancing the immunogenicity and cross-protection by influenza virus vaccination in young and aged mice
2021 · Noopur Bhatnagar, Ki-Hye Kim, et al. · Antiviral Research · 16
Enhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes
2021 · Bo Ryoung Park, Jeeva Subbiah, et al. · Virology · 6
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Functional NK Cell Activation by Ovalbumin Immunization with a Monophosphoryl Lipid A and Poly I:C Combination Adjuvant Promoted Dendritic Cell Maturation
2021 · Chau Thuy Tien Le, So Yeon Ahn, et al. · Vaccines · 8
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An Update on mRNA-Based Viral Vaccines
2021 · Subbiah Jeeva, Ki-Hye Kim, et al. · Vaccines · 50
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Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome
2021 · Chong-Hyun Shin, Ki-Hye Kim, et al. · Cells · 9
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BCG Cell Wall Skeleton As a Vaccine Adjuvant Protects Both Infant and Old-Aged Mice from Influenza Virus Infection
2021 · Ki-Hye Kim, Young-Tae Lee, et al. · Biomedicines · 15
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Natural killer cells contribute to enhanced respiratory disease after oil-in-water emulsion adjuvanted vaccination against respiratory syncytial virus and infection
2021 · Yoonsuh Park, Ki-Hye Kim, et al. · Human Vaccines & Immunotherapeutics
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Immunogenicity and Neutralizing Activity Comparison of SARS-CoV-2 Spike Full-Length and Subunit Domain Proteins in Young Adult and Old-Aged Mice
2021 · Ki-Hye Kim, Noopur Bhatnagar, et al. · Vaccines · 14
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Roles of the Fc Receptor γ-Chain in Inducing Protective Immune Responses after Heterologous Vaccination against Respiratory Syncytial Virus Infection
2021 · Hye Suk Hwang, Young-Tae Lee, et al. · Vaccines · 2
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Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin
2021 · Bo Ryoung Park, Ki-Hye Kim, et al. · Scientific Reports · 20
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A Strategy to Elicit M2e-Specific Antibodies Using a Recombinant H7N9 Live Attenuated Influenza Vaccine Expressing Multiple M2e Tandem Repeats
2021 · Daria Mezhenskaya, Irina Isakova-Sivak, et al. · Biomedicines · 12
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Recombinant Live Attenuated Influenza Virus Expressing Conserved G-Protein Domain in a Chimeric Hemagglutinin Molecule Induces G-Specific Antibodies and Confers Protection against Respiratory Syncytial Virus
2020 · Yu-Jin Jung, Yu-Na Lee, et al. · Vaccines · 8
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TBK1 regulates regeneration of pancreatic β-cells
2020 · Yun-Fang Jia, Subbiah Jeeva, et al. · Scientific Reports · 10
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