CopN mechanism as a key to understanding Type Three Secretion in bacteria
Description: PUBLIC HEALTH RELEVANCE: Despite evident need, new antibiotics are not being developed at an adequate rate and most effort involves modifications of existing drugs, rather than identification and development of novel drug targets. An attractive target for the much-needed development of new antibiotic therapeutics is the Type Three Secretion System (T3SS), a virulence factor delivery machine that is conserved among over 25 species of Gram-negative bacteria (including category A, B, and C pathogens and new CDC category of urgent threats). We have discovered that a novel molecular scaffold is a critical feature of T3SS and will further elucidate its role in the hierarchy of secretion in multiple gram-negative bacteria as well as test the hypothesis that this molecular scaffold is a useful target for novel antibiotics.
Funding type: research
Funder scheme: R01
Start date: 2014-07-01
End date: 2021-06-30
Investigator: BENJAMIN W SPILLER
Institution: VANDERBILT UNIVERSITY
Subfield: Genetics
Domain: Life Sciences
Funded outputs count: 8
Funder award ID: R01AI108778
OpenAlex ID: G4708635570