Islet Cell Growth Factors Focusing on Endocrine-External Secretory Linkage and Their Therapeutic Application
Description: Since endocrine and exocrine cells develop almost simultaneously during embryonic organogenesis, it has been believed that there is some cross-talk between the two. In this study, we searched for novel factors responsible for crosstalk and found the chemokine CCL5 as a candidate factor, and furthermore, the exocrine cell-derived factor CCL5 was found to be a factor that can regulate proliferation of adult endocrine cells (β cells). Furthermore, we found that Pdx1 expression in exocrine cells of embryonic mice stimulates CCL5 secretion, and that CCL5 reaching endocrine tissues promotes β-cell proliferation through GPR75 receptors on β-cells.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2022-03-31
Investigator: Toshihiko Masui
Institution: Kyoto University
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Funded outputs count: 8
Funder award ID: 18K08677
OpenAlex ID: G4731894271