The contribution of bacteriophages to host-microbe interactions in the intestine
Description: PUBLIC HEALTH RELEVANCE: The mammalian intestine contains a diverse array of microbes including intestinal viruses that infect bacteria called bacteriophages (phages). Virtually nothing is known about how phages contribute to the microbial functionality of the intestine and whether they have any influence on human physiology. For this proposal, I will use Enterococcus faecalis phages as a model system to discover the mechanisms that elicit phage production in the intestine, to determine how phages impact host immunity, and to explore whether phage predation impacts bacterial interactions within the host, which will set the stage for understanding the roles of phages during intestinal health and disease.
Funding type: career_development
Funder scheme: K01
Start date: 2014-09-15
End date: 2019-08-31
Investigator: BRECK A DUERKOP
Institution: UNIVERSITY OF COLORADO DENVER
Subfield: Ecology
Field: Environmental Science
Domain: Physical Sciences
Funded outputs count: 13
Funder award ID: K01DK102436
OpenAlex ID: G4762760674