The Role of the Immune Response in Controlling the Size of the HIV Reservoir.
Description: A special category of HIV infected individuals, called elite suppressors, control HIV viral load to undetectable levels in the absence of antiviral therapy. The proposed experiments investigate the mechanism behind the ability of elite suppressors to maintain a smaller reservoir. Our studies suggest that elite suppressors have immune activity against treatment resistant reservoir cells and may lead to future therapies that harness the immune response to reduce reservoir size in patients receiving antiviral therapy.
Funding type: research
Funder scheme: R21
Start date: 2011-09-20
End date: 2014-08-31
Investigator: UNA T O'DOHERTY
Institution: UNIVERSITY OF PENNSYLVANIA
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 5
Funder award ID: R21AI096993
OpenAlex ID: G4790464433