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Control of Retrovirus Assembly by Membrane Lipid Thermodynamic Activity.

Description: PUBLIC HEALTH RELEVANCE: Useful treatments for viral afflictions, in particular HIV-AIDS, are not limited to "all or none" cures, and combinations of drugs, each of which slows down a step of the viral life cycle, have proven useful. The proposed studies will identify the membrane lipid compositions that are favorable for virus assembly, and those that inhibit. Studies of virus assembly in model membranes and in living cells could provide a basis for reducing viral load by manipulation of membrane bilayer phase behaviors via alteration of membrane lipid compositions.
Funding type: research
Funder scheme: R01
Start date: 2013-09-15
End date: 2018-12-31
Investigator: GERALD WILLIAM FEIGENSON
Institution: CORNELL UNIVERSITY
Funded outputs count: 22
Funder award ID: R01GM105684
OpenAlex ID: G4792123807
Dataset of asymmetric giant unilamellar vesicles prepared via hemifusion: Observation of anti-alignment of domains and modulated phases in asymmetric bilayers.
2021 · Thais A. Enoki, Joy Wu, et al. · Data in Brief · 13
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Investigation of the domain line tension in asymmetric vesicles prepared via hemifusion
2021 · Thais A. Enoki, Joy Wu, et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 24
Bilayer compositional asymmetry influences the nanoscopic to macroscopic phase domain size transition
2020 · Naveen Mohideen, Michael D. Weiner, et al. · Chemistry and Physics of Lipids · 7
Mechanisms of PI(4,5)P2 Enrichment in HIV-1 Viral Membranes
2020 · Yi Wen, Gerald W. Feigenson, et al. · Journal of Molecular Biology · 34
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Calculation of Liquid-Disordered/Liquid-Ordered Line Tension from Pairwise Lipid Interactions
2020 · J. Huang, S. Hiraki, et al. · The Journal of Physical Chemistry B · 14
Asymmetric Bilayers by Hemifusion: Method and Leaflet Behaviors
2019 · Thais A. Enoki, Gerald W. Feigenson · Biophysical Journal · 63
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Lowering line tension with high cholesterol content induces a transition from macroscopic to nanoscopic phase domains in model biomembranes
2018 · Wen-Chyan Tsai, Gerald W. Feigenson · Biochimica et Biophysica Acta (BBA) - Biomembranes · 36
Inositol phosphates are assembly co-factors for HIV-1
2018 · Robert A. Dick, Kaneil K. Zadrozny, et al. · Nature · 253
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Multivalent Cation-Bridged PI(4,5)P2 Clusters Form at Very Low Concentrations
2018 · Yi Wen, Volker M. Vogt, et al. · Biophysical Journal · 74
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Membrane Bending Moduli of Coexisting Liquid Phases Containing Transmembrane Peptide
2018 · Rebecca D. Usery, Thais A. Enoki, et al. · Biophysical Journal · 27
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FRET Detects the Size of Nanodomains for Coexisting Liquid-Disordered and Liquid-Ordered Phases
2018 · Thais A. Enoki, Frederick A. Heberle, et al. · Biophysical Journal · 45
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Cholesterol Promotes Protein Binding by Affecting Membrane Electrostatics and Solvation Properties
2017 · Milka Doktorova, Frederick A. Heberle, et al. · Biophysical Journal · 48
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Line Tension Controls Liquid-Disordered + Liquid-Ordered Domain Size Transition in Lipid Bilayers
2017 · Rebecca D. Usery, Thais A. Enoki, et al. · Biophysical Journal · 95
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Effects of Membrane Charge and Order on Membrane Binding of the Retroviral Structural Protein Gag
2016 · Yi Wen, Robert A. Dick, et al. · Journal of Virology · 24
Subnanometer Structure of an Asymmetric Model Membrane: Interleaflet Coupling Influences Domain Properties
2016 · Frederick A. Heberle, Drew Marquardt, et al. · Langmuir · 125
Effects of Transmembrane α-Helix Length and Concentration on Phase Behavior in Four-Component Lipid Mixtures: A Molecular Dynamics Study
2016 · David G. Ackerman, Gerald W. Feigenson · The Journal of Physical Chemistry B · 12
Phase diagram of a polyunsaturated lipid mixture: Brain sphingomyelin/1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine/cholesterol
2015 · Tatyana M. Konyakhina, Gerald W. Feigenson · Biochimica et Biophysica Acta (BBA) - Biomembranes · 60
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Pictures of the Substructure of Liquid-Ordered Domains
2015 · Gerald W. Feigenson · Biophysical Journal · 10
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Lipid bilayers: clusters, domains and phases
2015 · David G. Ackerman, Gerald W. Feigenson · Essays in Biochemistry · 62
Multiscale Modeling of Four-Component Lipid Mixtures: Domain Composition, Size, Alignment, and Properties of the Phase Interface
2015 · David G. Ackerman, Gerald W. Feigenson · The Journal of Physical Chemistry B · 84
Lattice simulations of phase morphology on lipid bilayers: Renormalization, membrane shape, and electrostatic dipole interactions
2014 · Jonathan J. Amazon, Gerald W. Feigenson · Physical Review E · 44
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