Award

Senescence bypass in epithelial neoplastic progression

Funder: National Institute of Dental and Craniofacial Research

Funding type: research

Funder scheme: R01

Start date: 2000-09-01

End date: 2010-06-30

Investigator: JAMES RHEINWALD

Institution: BRIGHAM AND WOMEN'S HOSPITAL

Funded outputs count: 9

Funder award ID: R01DE013178

OpenAlex ID: G4804635369

MAPK/ERK-Dependent Translation Factor Hyperactivation and Dysregulated Laminin γ2 Expression in Oral Dysplasia and Squamous Cell Carcinoma

2012 · Martin Degen, Easwar Natarajan, et al. · American Journal Of Pathology · 66

Modulation of TGF-β-inducible hypermotility by EGF and other factors in human prostate epithelial cells and keratinocytes

2010 · Wei Wei, Patricia D. Barron, et al. · In Vitro Cellular & Developmental Biology - Animal · 7

Epithelial Cells Derived from Human Embryonic Stem Cells Display P16INK4A Senescence, Hypermotility, and Differentiation Properties Shared by Many P63+ Somatic Cell Types

2009 · Sally Dabelsteen, Paula Hercule, et al. · Stem Cells · 56

A Keratinocyte Hypermotility/Growth-Arrest Response Involving Laminin 5 and p16INK4A Activated in Wound Healing and Senescence

2006 · Easwar Natarajan, John D. Omobono, et al. · American Journal Of Pathology · 74

Immortalized keratinocyte lines derived from human embryonic stem cells

2006 · Shiro Iuchi, Sally Dabelsteen, et al. · Proceedings of the National Academy of Sciences · 72

Co-expression of p16INK4A and Laminin 5 by Keratinocytes: A Wound-Healing Response Coupling Hypermotility with Growth Arrest that Goes Awry During Epithelial Neoplastic Progression

2005 · Easwar Natarajan, John D. Omobono, et al. · Journal of Investigative Dermatology Symposium Proceedings · 33

Selective suppression of monocyte chemoattractant protein‐1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells

2003 · Kerstin Kleine‐Lowinski, James G. Rheinwald, et al. · International Journal of Cancer · 71

Co-Expression of p16INK4A and Laminin 5 γ2 by Microinvasive and Superficial Squamous Cell Carcinomas in Vivo and by Migrating Wound and Senescent Keratinocytes in Culture

2003 · Easwar Natarajan, Marcela Saeb, et al. · American Journal Of Pathology · 114

A Two-Stage, p16 INK4A - and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status

2002 · James G. Rheinwald, William C. Hahn, et al. · Molecular and Cellular Biology · 338