Mechanisms of Genomic Imprinting
Description: We propose to test the role of DNA cytosine hydroxymethylation and chromatin in the erasure, establishment and maintenance of genomic imprints. Experiments using genome-wide mapping methods, novel allele- specific assays and mouse genetic tools will collectively help understand how DNA methylation, DNA hydroxymethylation and chromatin marks collaborate in the global epigenetic remodeling of germ cells and in erasing, establishing and maintaining genomic imprints. Correct global epigenetic remodeling and imprint resetting during embryonic-fetal germ cell development is essential for the health of the next generation and for future generations.
Funding type: research
Funder scheme: R01
Start date: 2002-04-01
End date: 2018-04-30
Investigator: PIROSKA EDIT SZABÓ
Institution: VAN ANDEL RESEARCH INSTITUTE
Subfield: Genetics
Domain: Life Sciences
Funded outputs count: 32
Funder award ID: R01GM064378
OpenAlex ID: G4820006263