A multifunctional nanomaterial platform for reducing morbidity in medulloblastoma therapy
Description: This project will evaluate a novel biocompatible nanomaterial in preclinical studies to allow its clinical translation for NIR fluorescence and MRI image-guided surgery and sonodynamic therapy of medulloblastoma (MB). Based on our strong preliminary data, we hypothesize that this multifunctional nanomaterial platform can be transported across the blood-brain barrier and accumulate in MB tumors to enable their multimodal detection and safer therapy using non-ionizing low-intensity ultrasound. Translating this technology to the clinic would be transformative in managing MB by significantly reducing morbidities associated with surgery and chemoradiotherapy of MB tumors.
Funder: National Institutes of Health
Amount: $231,500
Funding type: research
Funder scheme: R21
Start date: 2023-12-18
End date: 2025-11-30
Investigator: RAMON FRANCISCO BARAJAS
Institution: OREGON HEALTH & SCIENCE UNIVERSITY
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Funded outputs count: 1
Funder award ID: 1r21ns135452-01
OpenAlex ID: G4844552325