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Role of the kallikrein-kinin system in diabetic retinopathy

Description: PUBLIC HEALTH RELEVANCE: Diabetes macular edema is a leading cause of vision loss. Recent studies have revealed that an enzyme named plasma kallikrein in increased in the vitreous of people with diabetic retinopathy and contributes impairment to retinal vascular dysfunction via a pathway that is VEGF independent. This grant will perform studies using both knockout animal models and pharmacological approaches to identify the mechanisms of plasma kallikrein's effects on the retina and potential crosstalk with the VEGF pathway.
Funding type: research
Funder scheme: R01
Start date: 2008-09-01
End date: 2018-03-31
Investigator: LLOYD P AIELLO
Institution: JOSLIN DIABETES CENTER
Subfield: Genetics
Field: Medicine
Funded outputs count: 38
Funder award ID: R01EY019029
OpenAlex ID: G4889415366
Retinal proteome associated with bradykinin-induced edema
2019 · Nivetha Murugesan, Ward Fickweiler, et al. · Experimental Eye Research · 12
Choroidal thickness in older patients with central serous chorioretinopathy
2016 · Caio V. Regatieri, Eduardo A. Novais, et al. · International Journal of Retina and Vitreous · 12
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Plasma Kallikrein Mediates Vascular Endothelial Growth Factor–Induced Retinal Dysfunction and Thickening
2016 · Allen Clermont, Nivetha Murugesan, et al. · Investigative Ophthalmology & Visual Science · 34
Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction
2015 · Yan-Min Long, Xing-Chen Zhao, et al. · Nanotoxicology · 33
Thrombosis and Hemorrhage in Diabetic Retinopathy: A Perspective from an Inflammatory Standpoint
2015 · Nivetha Murugesan, Tuna Üstunkaya, et al. · Seminars in Thrombosis and Hemostasis · 58
Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema
2015 · Takeshi Kita, Allen C. Clermont, et al. · Diabetes · 91
Analysis of Short-Term Change in Subfoveal Choroidal Thickness in Eyes With Age-Related Macular Degeneration Using Optical Coherence Tomography
2014 · Jordana G. Fein, Lauren A. Branchini, et al. · Ophthalmic surgery, lasers & imaging retina · 20
Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror
2013 · Chen D. Lu, Martin F. Kraus, et al. · Biomedical Optics Express · 188
Reproducibility of a Long-Range Swept-Source Optical Coherence Tomography Ocular Biometry System and Comparison with Clinical Biometers
2013 · Ireneusz Grulkowski, Jonathan J. Liu, et al. · Ophthalmology · 97
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Analysis of Choroidal Morphologic Features and Vasculature in Healthy Eyes Using Spectral-Domain Optical Coherence Tomography
2013 · Lauren A. Branchini, Mehreen Adhi, et al. · Ophthalmology · 282
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Functional imaging of hemodynamic stimulus response in the rat retina with ultrahigh-speed spectral / Fourier domain OCT
2013 · WooJhon Choi, Bernhard Baumann, et al. · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · 3
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Effect of Intravitreous Anti–Vascular Endothelial Growth Factor Therapy on Choroidal Thickness in Neovascular Age-Related Macular Degeneration Using Spectral-Domain Optical Coherence Tomography
2013 · Lauren Branchini, Caio Regatieri, et al. · JAMA Ophthalmology · 59
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High-precision, high-accuracy ultralong-range swept-source optical coherence tomography using vertical cavity surface emitting laser light source
2013 · Ireneusz Grulkowski, Jonathan J. Liu, et al. · Optics Letters · 128
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Plasma kallikrein-kinin system and diabetic retinopathy
2013 · Jia Liu, Edward P. Feener · Biological Chemistry · 74
In vivo imaging of the rodent eye with swept source/Fourier domain OCT
2013 · Jonathan J. Liu, Ireneusz Grulkowski, et al. · Biomedical Optics Express · 23
Phase-sensitive swept-source optical coherence tomography imaging of the human retina with a vertical cavity surface-emitting laser light source
2013 · WooJhon Choi, Benjamin Potsaid, et al. · Optics Letters · 118
Intraocular Hemorrhage Causes Retinal Vascular Dysfunction via Plasma Kallikrein
2013 · Jia Liu, Allen C. Clermont, et al. · Investigative Ophthalmology & Visual Science · 25
Role of plasma kallikrein in diabetes and metabolism
2013 · Qunfang Zhou, Ward Fickweiler, et al. · Thrombosis and Haemostasis · 56
Extracting and compensating dispersion mismatch in ultrahigh-resolution Fourier domain OCT imaging of the retina
2012 · WooJhon Choi, Bernhard Baumann, et al. · Optics Express · 27
Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers
2012 · Ireneusz Grulkowski, Jonathan J. Liu, et al. · Biomedical Optics Express · 309
Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns
2012 · Martin F. Kraus, Benjamin Potsaid, et al. · Biomedical Optics Express · 366
Measurement of pulsatile total blood flow in the human and rat retina with ultrahigh speed spectral/Fourier domain OCT
2012 · WooJhon Choi, Bernhard Baumann, et al. · Biomedical Optics Express · 80
Swept source / Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit
2012 · Bernhard Baumann, WooJhon Choi, et al. · Optics Express · 130
Choroidal Imaging Using Spectral-domain Optical Coherence Tomography
2012 · Caio V. Regatieri, Lauren Branchini, et al. · Retina · 149
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke
2012 · Long-Jun Wu, Gongxiong Wu, et al. · Nature Neuroscience · 252
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