Organization and dynamics of multiregional circuits for goal-directed behaviour
Description: Many of the brain’s important functions engage computations across multiple brain regions, but the ways in which different regions collaborate remain poorly understood. The goal of this proposal is to identify the organizing principles and functional roles of long-range circuits between the cerebellum and the forebrain. The cerebellum’s role in sensorimotor learning is well established, while its contributions to cognitive behaviours, such as processing of reward, have only recently been appreciated. Here, I aim to create a unified understanding of these seemingly distinct functional roles by defining common principles of multi-regional computations performed by cerebellar circuits and their partners in the motor cortex and basal ganglia, which may facilitate sensorimotor and reward-related functions, respectively. To achieve this goal, I will utilise a combination of cutting-edge techniques in mice to (1) map the organizational logic of connections between the cerebellum and forebrain, (2) uncover shared activity patterns in these long- range circuits, and (3) define causal contributions of the cerebellum to computations in partner regions and to behaviour. This work will generate new insights into the cerebellum’s diverse roles and provide a rigorous foundation for quantitative, multiscale theories of learning and computation that can be applied throughout the brain.
Funder: Wellcome Trust
Amount: £3,246,000
Funding type: fellowship
Funder scheme: Brain and Behavioural Sciences
Start date: 2023-02-01
End date: 2031-06-30
Investigator: Dimitar Kostadinov
Institution: University College London
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 3
Funder award ID: 225951
OpenAlex ID: G4896983633