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Mapping cancer micro-environments for acute leukemia

Description: In this application we will map T cell acute leukemia niches in the bone marrow, and test the potential of targeting leukemia's interaction with the microenvironment as a novel therapeutic avenue for this aggressive blood malignancy.  
Funding type: research
Funder scheme: R01
Start date: 2016-09-01
End date: 2021-07-31
Investigator: IANNIS AIFANTIS
Institution: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
Funded outputs count: 31
Funder award ID: R01CA202025
OpenAlex ID: G4979167166
The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity
2024 · Kathryn Hockemeyer, Theodore Sakellaropoulos, et al. · Nature Cell Biology · 15
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Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia
2023 · Christina Glytsou, Xufeng Chen, et al. · Cancer Discovery · 83
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SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2
2021 · Qiao Lu, Jia Liu, et al. · Immunity · 158
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Monocyte-derived S1P in the lymph node regulates immune responses
2021 · Audrey Baeyens, Sabrina Bracero, et al. · Nature · 78
Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation
2021 · Eric Wang, Hua Zhou, et al. · Cell stem cell · 65
Leukemia-on-a-chip: Dissecting the chemoresistance mechanisms in B cell acute lymphoblastic leukemia bone marrow niche
2020 · Chao Ma, Matthew T. Witkowski, et al. · Science Advances · 91
Cell-by-Cell Deconstruction of Stem Cell Niches
2020 · Anastasia N. Tikhonova, Audrey Lasry, et al. · Cell stem cell · 29
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Faculty Opinions recommendation of The bone marrow microenvironment at single-cell resolution.
2020 · Simón Méndez-Ferrer · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia
2020 · Matthew T. Witkowski, Igor Dolgalev, et al. · Cancer Cell · 193
Finding a Way Out: S1P Signaling and Immune Cell Migration
2020 · Audrey A.L. Baeyens, Susan R. Schwab · Annual Review of Immunology · 123
Gut-resident CX3CR1 hi macrophages induce tertiary lymphoid structures and IgA response in situ
2020 · Balázs Koscsó, Sravya Kurapati, et al. · Science Immunology · 119
Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia
2020 · Andreas Kloetgen, Palaniraja Thandapani, et al. · Nature Genetics · 222
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On Epigenetic Plasticity and Genome Topology
2020 · Charalampos Lazaris, Iannis Aifantis, et al. · Trends in cancer · 6
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Siah2 control of T-regulatory cells limits anti-tumor immunity
2020 · Marzia Scortegagna, Kathryn Hockemeyer, et al. · Nature Communications · 29
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Mapping and targeting of the leukemic microenvironment
2019 · Matthew T. Witkowski, Stavroula Kousteni, et al. · The Journal of Experimental Medicine · 44
Immune-Based Therapies in Acute Leukemia
2019 · Matthew T. Witkowski, Audrey Lasry, et al. · Trends in cancer · 63
Dynamic CD138 surface expression regulates switch between myeloma growth and dissemination
2019 · Ilseyar Akhmetzyanova, Mark J. McCarron, et al. · Leukemia · 82
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction
2019 · Nicholas Collins, Seong-Ji Han, et al. · Cell · 272
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Secrets and lyase: Control of sphingosine 1‐phosphate distribution
2019 · Dhaval Dixit, Martyna Okuniewska, et al. · Immunological Reviews · 24
The bone marrow microenvironment at single-cell resolution
2019 · Anastasia N. Tikhonova, Igor Dolgalev, et al. · Nature · 931
CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration
2019 · Yanbao Xiong, Wenji Piao, et al. · Science Immunology · 104
PreB cells are moving on
2018 · Dhaval Dixit, Susan R. Schwab · The Journal of Experimental Medicine
STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia
2018 · Shella Saint Fleur-Lominy, Mate Maus, et al. · Cell Reports · 31
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Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia
2018 · Nikos Kourtis, Charalampos Lazaris, et al. · Nature Medicine · 87
High male sexual investment as a driver of extinction in fossil ostracods
2018 · Maria João Fernandes Martins, T. Markham Puckett, et al. · Nature · 93
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