PKA and Epac1 inhibit TLR4 to protect the diabetic retina
Description: We have previously reported that β- ‐adrenergic receptors can reduce TLR4 in the diabetic retina. The goal of this proposal is the potential mechanisms by which PKA or Epac1 are responsible for the β- ‐adrenergic regulation of TLR4. Inhibition of TLR4 by either PKA or Epac1 will likely lay the groundwork for new therapeutic development for diabetic retinopathy.
Funder: National Eye Institute
Funding type: research
Funder scheme: R01
Start date: 2020-01-01
End date: 2025-12-31
Investigator: JENA J STEINLE
Institution: WAYNE STATE UNIVERSITY
Funded outputs count: 21
Funder award ID: R01EY030284
OpenAlex ID: G4987911090