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Derivation of Heart Cells from Human Embryonic and Induced Pluripotent Stem Cells

Description: This research will lead to the production of pure, well-characterized ISL1+ cardiovascular progenitor cells and ventricular cardiomyocytes as an abundant renewable cell source for cardiac repair. Development of engineered cardiac tissues using human ES and iPS cell cultures will provide exciting opportunities for high- throughput, patient-specific evaluation of cardiac medicines and cell-based therapies for heart failure.
Funding type: career_development
Funder scheme: K02
Start date: 2010-07-15
End date: 2015-05-31
Investigator: YIBING QYANG
Institution: YALE UNIVERSITY
Funded outputs count: 21
Funder award ID: K02HL101990
OpenAlex ID: G4990366396
Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy
2022 · Muhammad Riaz, Jinkyu Park, et al. · Circulation · 50
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Modeling elastin-associated vasculopathy with patient induced pluripotent stem cells and tissue engineering
2018 · Matthew W. Ellis, Jiesi Luo, et al. · Cellular and Molecular Life Sciences · 12
Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering
2017 · Jiesi Luo, Lingfeng Qin, et al. · Biomaterials · 44
Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies
2017 · Christopher W. Anderson, Nicole Boardman, et al. · Current Cardiology Reports · 9
Anisotropic engineered heart tissue made from laser-cut decellularized myocardium
2016 · Jonas Schwan, Andrea T. Kwaczala, et al. · Scientific Reports · 95
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ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction
2016 · Oscar Bartulos, Zhen Wu Zhuang, et al. · JCI Insight · 33
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Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells
2016 · Biraja C. Dash, Karen Levi, et al. · Stem Cell Reports · 89
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Implantable tissue-engineered blood vessels from human induced pluripotent stem cells
2016 · Liqiong Gui, Biraja C. Dash, et al. · Biomaterials · 131
Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor
2015 · Amogh Sivarapatna, Mahboobe Ghaedi, et al. · Biomaterials · 110
Induced pluripotent stem cell-derived vascular smooth muscle cells: methods and application
2015 · Biraja C. Dash, Zhengxin Jiang, et al. · Biochemical Journal · 56
Functional Cardiomyocytes Derived from Isl1 Cardiac Progenitors via Bmp4 Stimulation
2014 · Esra Cagavi, Oscar Bartulos, et al. · PLoS ONE · 27
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Advancements in Induced Pluripotent Stem Cell Technology for Cardiac Regenerative Medicine
2014 · Carol Y. Suh, Zelun Wang, et al. · Journal of Cardiovascular Pharmacology and Therapeutics · 7
Bone Morphogenetic Protein 2 Signaling Negatively Modulates Lymphatic Development in Vertebrate Embryos
2013 · William P. Dunworth, Jose Cardona-Costa, et al. · Circulation Research · 107
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Modeling Supravalvular Aortic Stenosis Syndrome With Human Induced Pluripotent Stem Cells
2012 · Xin Ge, Yongming Ren, et al. · Circulation · 124
Context-Dependent Proangiogenic Function of Bone Morphogenetic Protein Signaling Is Mediated by Disabled Homolog 2
2012 · Jun-Dae Kim, Hyeseon Kang, et al. · Developmental Cell · 67
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Regenerating functional heart tissue for myocardial repair
2012 · Andre Alcon, Esra Cagavi Bozkulak, et al. · Cellular and Molecular Life Sciences · 56
Evaluation of the use of an induced puripotent stem cell sheet for the construction of tissue-engineered vascular grafts
2012 · Narutoshi Hibino, Daniel R. Duncan, et al. · Journal of Thoracic and Cardiovascular Surgery · 107
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High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells
2011 · Min Young Lee, Esra Cagavi Bozkulak, et al. · Biochemical and Biophysical Research Communications · 24
Methods of Cell Purification: A Critical Juncture for Laboratory Research and Translational Science
2011 · Peter J. Amos, Esra Cagavi Bozkulak, et al. · Cells Tissues Organs · 31
Derivation of functional ventricular cardiomyocytes using endogenous promoter sequence from murine embryonic stem cells
2011 · Min Young Lee, Baonan Sun, et al. · Stem Cell Research · 9
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Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells
2011 · Yongming Ren, Min Young Lee, et al. · Journal of Molecular and Cellular Cardiology · 152
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