Get started
Award

Properties of Specific Alcohol Binding Sites

Funding type: research
Funder scheme: R01
Start date: 2001-12-01
End date: 2011-06-30
Investigator: JAMES ROBERT TRUDELL
Institution: STANFORD UNIVERSITY
Funded outputs count: 42
Funder award ID: R01AA013378
OpenAlex ID: G4997417543
Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor
2016 · Mandy L. McCracken, Giorgio Gorini, et al. · Frontiers in Molecular Neuroscience · 7
PDF
Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Humanα1 Glycine Receptors
2015 · Suzzane Horani, Evan P. Stater, et al. · Alcoholism Clinical and Experimental Research · 5
Glycine and GABAA Ultra-Sensitive Ethanol Receptors as Novel Tools for Alcohol and Brain Research
2014 · Anna Naito, Karan H. Muchhala, et al. · Molecular Pharmacology · 14
Alcohol dependence: molecular and behavioral evidence
2014 · James R. Trudell, Robert O. Messing, et al. · Trends in Pharmacological Sciences · 98
PDF
Seeking Structural Specificity: Direct Modulation of Pentameric Ligand-Gated Ion Channels by Alcohols and General Anesthetics
2014 · Rebecca J. Howard, James R. Trudell, et al. · Pharmacological Reviews · 56
PDF
Structural Models of Ligand‐Gated Ion Channels: Sites of Action for Anesthetics and Ethanol
2013 · Richard W. Olsen, Guo‐Dong Li, et al. · Alcoholism Clinical and Experimental Research · 61
Zinc-Dependent Modulation of α2- and α3-Glycine Receptor Subunits by Ethanol
2013 · Lindsay M. McCracken, James R. Trudell, et al. · Alcoholism Clinical and Experimental Research · 18
Inhibition versus Potentiation of Ligand-Gated Ion Channels Can Be Altered by a Single Mutation that Moves Ligands between Intra- and Intersubunit Sites
2013 · Torben Brömstrup, Rebecca J. Howard, et al. · Structure · 25
PDF
Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors
2013 · Maya Popova, James Trudell, et al. · Purinergic Signalling · 34
PDF
Assessment of Homology Templates and an Anesthetic Binding Site within the γ-Aminobutyric Acid Receptor
2013 · Edward J. Bertaccini, Ozge Yoluk, et al. · Anesthesiology · 37
PDF
Mutation of a Zinc-Binding Residue in the Glycine Receptor α1 Subunit Changes Ethanol Sensitivity In Vitro and Alcohol Consumption In Vivo
2012 · Lindsay M. McCracken, Yuri A. Blednov, et al. · Journal of Pharmacology and Experimental Therapeutics · 26
PDF
Molecular Mechanism for the Dual Alcohol Modulation of Cys-loop Receptors
2012 · Samuel Murail, Rebecca J. Howard, et al. · PLoS Computational Biology · 37
PDF
Induced changes in protein receptors conferring resistance to anesthetics
2012 · Edward J. Bertaccini, James R. Trudell · Current Opinion in Anaesthesiology · 2
Charge and Geometry of Residues in the Loop 2 β Hairpin Differentially Affect Agonist and Ethanol Sensitivity in Glycine Receptors
2012 · Daya I. Perkins, James R. Trudell, et al. · Journal of Pharmacology and Experimental Therapeutics · 16
PDF
Ethanol Inhibition of Constitutively Open N-Methyl-d-Aspartate Receptors
2011 · Minfu Xu, C. Thetford Smothers, et al. · Journal of Pharmacology and Experimental Therapeutics · 27
PDF
Structural basis for alcohol modulation of a pentameric ligand-gated ion channel
2011 · Rebecca J. Howard, Samuel Murail, et al. · Proceedings of the National Academy of Sciences · 105
PDF
Alcohol-Binding Sites in Distinct Brain Proteins: The Quest for Atomic Level Resolution
2011 · Rebecca J. Howard, Paul A. Slesinger, et al. · Alcoholism Clinical and Experimental Research · 56
Microsecond Simulations Indicate that Ethanol Binds between Subunits and Could Stabilize an Open-State Model of a Glycine Receptor
2011 · Samuel Murail, Björn Wallner, et al. · Biophysical Journal · 73
PDF
Modeling Anesthetic Binding Sites within the Glycine Alpha One Receptor Based on Prokaryotic Ion Channel Templates: The Problem with TM4
2010 · Edward J. Bertaccini, Björn Wallner, et al. · Journal of Chemical Information and Modeling · 23
A Transmembrane Amino Acid in the GABAA Receptor β2 Subunit Critical for the Actions of Alcohols and Anesthetics
2010 · Mandy L. McCracken, Cecilia M. Borghese, et al. · Journal of Pharmacology and Experimental Therapeutics · 25
PDF
Ivermectin Antagonizes Ethanol Inhibition in Purinergic P2X4 Receptors
2010 · Liana Asatryan, Maya Popova, et al. · Journal of Pharmacology and Experimental Therapeutics · 56
PDF
Normal Mode Gating Motions of a Ligand-Gated Ion Channel Persist in a Fully Hydrated Lipid Bilayer Model
2010 · Edward J. Bertaccini, James R. Trudell, et al. · ACS Chemical Neuroscience · 6
Molecular targets and mechanisms for ethanol action in glycine receptors
2010 · Daya I. Perkins, James R. Trudell, et al. · Pharmacology & Therapeutics · 60
Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation
2010 · Jelena Todorovic, Brian T. Welsh, et al. · Proceedings of the National Academy of Sciences · 16
Loop 2 Structure in Glycine and GABAA Receptors Plays a Key Role in Determining Ethanol Sensitivity
2009 · Daya I. Perkins, James R. Trudell, et al. · Journal of Biological Chemistry · 35
Year
Topic