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整合素结合性信号分子Kindlin-1与多种重要蛋白质相互作用：结构解析、生物学功能和作用机制研究

Amount: ¥500,000
Funding type: grant
Funder scheme: 面上项目
Start date: 2011-01-01
End date: 2015-12-31
Investigator: 宏权 张
Institution: 北京大学
Funded outputs count: 34
Funder award ID: 31170711
OpenAlex ID: G500925348
The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations
2022 · Tianzhuo Wang, Huiying Guo, et al. · Cell Reports · 15
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Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice
2021 · Xiaochun Chi, Weiwei Luo, et al. · Cell Death and Disease · 31
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Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1
2019 · Jiagui Song, Tianzhuo Wang, et al. · Cell Reports · 65
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HOX family transcription factors: Related signaling pathways and post-translational modifications in cancer
2019 · Miao Yu, Jun Zhan, et al. · Cellular Signalling · 71
HOXB13 networking with ABCG1/EZH2/Slug mediates metastasis and confers resistance to cisplatin in lung adenocarcinoma patients
2019 · Jun Zhan, Peng Wang, et al. · Theranostics · 61
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Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development
2018 · Peng Wang, Wenhui Chu, et al. · The International Journal of Biochemistry & Cell Biology · 38
HOXB9 acetylation at K27 is responsible for its suppression of colon cancer progression
2018 · Jiagui Song, Tianzhuo Wang, et al. · Cancer Letters · 28
Long non-coding RNA SNHG15 interacts with and stabilizes transcription factor Slug and promotes colon cancer progression
2018 · Hao Jiang, Tingting Li, et al. · Cancer Letters · 124
Kindlins: Roles in development and cancer progression
2018 · Jun Zhan, Hongquan Zhang · The International Journal of Biochemistry & Cell Biology · 72
GATA3 acetylation at K119 by CBP inhibits cell migration and invasion in lung adenocarcinoma
2018 · Xueying Li, Jiaqi Jin, et al. · Biochemical and Biophysical Research Communications · 23
Src-mediated phosphorylation converts FHL1 from tumor suppressor to tumor promoter
2018 · Xiang Wang, Xiaofan Wei, et al. · The Journal of Cell Biology · 35
Unconventional myosin VIIA promotes melanoma progression
2018 · Yuqing Liu, Xiaofan Wei, et al. · Journal of Cell Science · 22
Global profiling of crotonylation on non-histone proteins
2017 · Weizhi Xu, Junhu Wan, et al. · Cell Research · 209
Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation
2017 · Xiaofan Wei, Xiang Wang, et al. · The Journal of Cell Biology · 58
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Kindlin-2 promotes clear cell renal cell carcinoma progression through the Wnt signaling pathway
2017 · Muhan Li, Xuelian Pei, et al. · Oncology Reports · 10
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Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells
2016 · Jinfeng Kong, Juan Du, et al. · Oncotarget · 27
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Depletion of Kindlin-2 induces cardiac dysfunction in mice
2016 · Lihua Qi, Yu Yu, et al. · Science China Life Sciences · 13
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Biochemical and structural characterization of a DNA N6-adenine methyltransferase fromHelicobacter pylori
2016 · Bo Ma, Ji Ma, et al. · Oncotarget · 16
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Biochemical and structural characterization of a novel ubiquitin-conjugating enzyme E2 from Agrocybe aegeria reveals Ube2w family-specific properties
2015 · Chao Qi, De-Feng Li, et al. · Scientific Reports · 12
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Kindlin‐2 interacts with α‐actinin‐2 and β1 integrin to maintain the integrity of the Z‐disc in cardiac muscles
2015 · Lihua Qi, Yu Yu, et al. · FEBS Letters · 21
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PRC2 regulates RNA polymerase III transcribed non-translated RNA gene transcription through EZH2 and SUZ12 interaction with TFIIIC complex
2015 · Chang Liu, Shuai Li, et al. · Nucleic Acids Research · 22
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Kindlin‐2 phosphorylation by Src at Y193 enhances Src activity and is involved in Migfilin recruitment to the focal adhesions
2015 · Zhaoli Liu, Danyu Lu, et al. · FEBS Letters · 29
Enhanced IMP3 Expression Activates NF-кB Pathway and Promotes Renal Cell Carcinoma Progression
2015 · Xuelian Pei, Muhan Li, et al. · PLoS ONE · 40
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Kindlin-2 interacts with and stabilizes EGFR and is required for EGF-induced breast cancer cell migration
2015 · Baohui Guo, Jianchao Gao, et al. · Cancer Letters · 65
Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9
2015 · Jun Zhan, Jiagui Song, et al. · Cancer Letters · 60
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