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Inhibition of the tumor-promoting effects of TGF-beta in advanced prostate cancer

Description: PUBLIC HEALTH RELEVANCE: This research will investigate a promising new approach for treating advance androgen- independent prostate cancer, the second leading cause of cancer death in American men. The proposed strategy is to reduce the levels of transforming growth factor-beta, which is known to promote the progression of prostate cancer, including its metastasis to the bone and lungs, by neutralizing it with novel fusion proteins in which the extracellular domains of the transforming growth factor beta receptors are linked together by artificial linkers.
Funding type: research
Funder scheme: R01
Start date: 2013-07-01
End date: 2019-05-31
Investigator: ANDREW P HINCK
Institution: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
Funded outputs count: 25
Funder award ID: R01CA172886
OpenAlex ID: G504351007
Th1 differentiation and function are inhibited in neonates following human metapneumovirus infection
2025 · Emma Brown, Jie Lan, et al. · The Journal of Immunology · 5
Data from Novel TGFβ Inhibitors Ameliorate Oral Squamous Cell Carcinoma Progression and Improve the Antitumor Immune Response of Anti–PD-L1 Immunotherapy
2023 · Nils Ludwig, Łukasz Wieteska, et al.
Novel TGFβ Inhibitors Ameliorate Oral Squamous Cell Carcinoma Progression and Improve the Antitumor Immune Response of Anti–PD-L1 Immunotherapy
2021 · Nils Ludwig, Łukasz Wieteska, et al. · Molecular Cancer Therapeutics · 28
Gli2 mediates the development of castration‑resistant prostate cancer
2020 · Lu Xia, Hakim Bouamar, et al. · International Journal of Oncology · 13
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Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family
2019 · Sun Kyung Kim, Morkos A Henen, et al. · Experimental Biology and Medicine · 76
Structural Adaptation in Its Orphan Domain Engenders Betaglycan with an Alternate Mode of Growth Factor Binding Relative to Endoglin
2019 · Sun Kyung Kim, Matthew J. Whitley, et al. · Structure · 15
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TGF-β2 uses the concave surface of its extended finger region to bind betaglycan’s ZP domain via three residues specific to TGF-β and inhibin-α
2018 · Morkos A. Henen, Pardeep Mahlawat, et al. · Journal of Biological Chemistry · 23
Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism
2018 · Andrew P. Hinck · Bioorganic & Medicinal Chemistry · 11
Differential effects of GLI2 and GLI3 in regulating cervical cancer malignancy in vitro and in vivo
2018 · Haiyan Zhu, Lu Xia, et al. · Laboratory Investigation · 19
A Novel TGFβ Trap Blocks Chemotherapeutics-Induced TGFβ1 Signaling and Enhances Their Anticancer Activity in Gynecologic Cancers
2018 · Haiyan Zhu, Xiang Gu, et al. · Clinical Cancer Research · 64
TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition
2018 · Anassuya Ramachandran, Pedro Vizán, et al. · eLife · 204
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells
2017 · Chris J. C. Johnston, Danielle J. Smyth, et al. · Nature Communications · 197
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Correction to Binding Properties of the Transforming Growth Factor-? Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling
2017 · Maria M. Villarreal, Sun Kyung Kim, et al. · Biochemistry · 15
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Structural basis for potency differences between GDF8 and GDF11
2017 · Ryan G. Walker, Magdalena Czepnik, et al. · BMC Biology · 112
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An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling
2017 · Sun Kyung Kim, Lindsey Barron, et al. · Journal of Biological Chemistry · 43
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Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED
2017 · M Jason de la Cruz, Johan Hattne, et al. · Nature Methods · 160
Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling
2016 · Maria M. Villarreal, Sun Kyung Kim, et al. · Biochemistry · 45
A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands
2016 · Tai Qin, Lindsey Barron, et al. · Oncotarget · 40
TGF-β signal rewiring sustains epithelial-mesenchymal transition of circulating tumor cells in prostate cancer xenograft hosts
2016 · Guangcun Huang, Pawel A. Osmulski, et al. · Oncotarget · 22
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Structural Biology and Evolution of the TGF-β Family
2016 · Andrew P. Hinck, Thomas D. Mueller, et al. · Cold Spring Harbor Perspectives in Biology · 370
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Production, Isolation, and Structural Analysis of Ligands and Receptors of the TGF-β Superfamily
2015 · Tao Huang, Andrew P. Hinck · Methods in molecular biology · 35
Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer
2015 · Sweta Mishra, Qin Tai, et al. · Oncotarget · 61
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MicroRNA-21 inhibits p57Kip2 expression in prostate cancer
2014 · Sweta Mishra, Chun-Lin Lin, et al. · Molecular Cancer · 57
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Biological Activity Differences between TGF-β1 and TGF-β3 Correlate with Differences in the Rigidity and Arrangement of Their Component Monomers
2014 · Tao Huang, Seth L. Schor, et al. · Biochemistry · 77
TGF-β Antagonists: Same Knot, but Different Hold
2013 · Andrew P. Hinck, Tao Huang · Structure · 7
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