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Cancer Gene Discovery to Identify Targetable Targets

Description: PUBLIC HEALTH RELEVANCE: My work concerns the identification of genetic and genomic alterations that cause human cancer in order to develop novel targeted treatments for different human tumors.
Funding type: research
Funder scheme: R35
Start date: 2015-09-11
End date: 2022-08-31
Investigator: CARLO M CROCE
Institution: OHIO STATE UNIVERSITY
Funded outputs count: 121
Funder award ID: R35CA197706
OpenAlex ID: G5043633744
miR-155 impairs ICOSL and MHC-I expression in DLBCL lymphomas
2025 · Esmerina Tili, Teresa L. Commisso, et al. · Proceedings of the National Academy of Sciences · 7
Therapeutic advances in the targeting of ROR1 in hematological cancers
2024 · Adrian-Bogdan Tigu, Raluca Munteanu, et al. · Cell Death Discovery · 39
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Therapeutic advances of targeting receptor tyrosine kinases in cancer
2024 · Ciprian Tomuleasa, Adrian-Bogdan Tigu, et al. · Signal Transduction and Targeted Therapy · 267
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Poly(A)-specific RNase (PARN) generates and regulates miR-125a-5p 3’-isoforms, displaying an altered expression in breast cancer
2024 · Luisa Tomasello, Shoshanah M. Holub, et al. · Signal Transduction and Targeted Therapy · 9
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Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma
2024 · Gian Luca Rampioni Vinciguerra, Marina Capece, et al. · Signal Transduction and Targeted Therapy · 18
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Role of Fra-2 in cancer
2023 · Gian Luca Rampioni Vinciguerra, Marina Capece, et al. · Cell Death and Differentiation · 31
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Expression signature of human endogenous retroviruses in chronic lymphocytic leukemia
2023 · Alessandro La Ferlita, Giovanni Nigita, et al. · Proceedings of the National Academy of Sciences · 13
A novel auxin-inducible degron system for rapid, cell cycle-specific targeted proteolysis
2023 · Marina Capece, Anna Tessari, et al. · Cell Death and Differentiation · 11
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MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies
2023 · Taewan Kim, Carlo M. Croce · Experimental & Molecular Medicine · 416
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Zinc treatment reverses and anti-Zn-regulated miRs suppress esophageal carcinomas in vivo
2023 · Louise Y. Fong, Kay Huebner, et al. · Proceedings of the National Academy of Sciences · 15
Data from Pan-Cancer Analysis of Canonical and Modified miRNAs Enhances the Resolution of the Functional miRNAome in Cancer
2023 · Rosario Distefano, Luisa Tomasello, et al.
Role of the miR-301a/Fra-2/GLIPR1 axis in lung cancer cisplatin resistance
2023 · Gian Luca Rampioni Vinciguerra, Marina Capece, et al. · Signal Transduction and Targeted Therapy · 18
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Pan-Cancer Analysis of Canonical and Modified miRNAs Enhances the Resolution of the Functional miRNAome in Cancer
2022 · Rosario Distefano, Luisa Tomasello, et al. · Cancer Research · 18
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tRNA-derived fragments (tRFs) in cancer
2022 · Yuri Pekarsky, Veronica Balatti, et al. · Journal of Cell Communication and Signaling · 51
A novel auxin-inducible degron system for rapid, cell cycle-specific targeted proteolysis
2022 · Dario Palmieri, Marina Capece, et al. · Research Square
A large fraction of trisomy 12, 17p − , and 11q − CLL cases carry unidentified microdeletions of miR-15a/16-1
2022 · Felice Pepe, Laura Z. Rassenti, et al. · Proceedings of the National Academy of Sciences · 11
PDCD1 (PD-1) is a direct target of miR-15a-5p and miR-16-5p
2022 · Alexey Palamarchuk, Liudmyla Tsyba, et al. · Signal Transduction and Targeted Therapy · 16
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Synergistic apoptotic effect of miR-183-5p and Polo-Like kinase 1 inhibitor NMS-P937 in breast cancer cells
2021 · Masahisa Kudo, Nicole Zalles, et al. · Cell Death and Differentiation · 10
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MiREDiBase, a manually curated database of validated and putative editing events in microRNAs
2021 · Gioacchino P. Marceca, Rosario Distefano, et al. · Scientific Data · 42
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The MicroRNA Family Gets Wider: The IsomiRs Classification and Role
2021 · Luisa Tomasello, Rosario Distefano, et al. · Frontiers in Cell and Developmental Biology · 119
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Predicting ROR1/BCL2 combination targeted therapy of small cell carcinoma of the lung
2021 · Walter Z. Wang, Konstantin Shilo, et al. · Cell Death and Disease · 22
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A concurrent canonical and modified miRNAome pan-cancer study on TCGA and TARGET cohorts leads to an enhanced resolution in cancer
2021 · Rosario Distefano, Luisa Tomasello, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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Frontiers of MicroRNA Signature in Non-small Cell Lung Cancer
2021 · Xinping Zhu, Masahisa Kudo, et al. · Frontiers in Cell and Developmental Biology · 62
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Detecting and Characterizing A-To-I microRNA Editing in Cancer
2021 · Gioacchino P. Marceca, Luisa Tomasello, et al. · Cancers · 34
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Loss of expression of both miR-15/16 loci in CML transition to blast crisis
2021 · Francesca Lovat, Pierluigi Gasparini, et al. · Proceedings of the National Academy of Sciences · 8
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