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R01 CA136851

Funded outputs count: 29
Funder award ID: R01 CA136851
OpenAlex ID: G5083175212
Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase
2023 · Younghoon Kim, Pooreum Seo, et al. · Cell chemical biology · 37
Recent Advances in Selective and Irreversible Covalent Ligand Development and Validation
2019 · Tinghu Zhang, John M. Hatcher, et al. · Cell chemical biology · 170
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Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK)
2018 · Chelsea E. Powell, Yang Gao, et al. · Journal of Medicinal Chemistry · 189
SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
2018 · John M. Hatcher, Guowei Wu, et al. · Cell chemical biology · 131
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Discovery of a potent dual ALK and EGFR T790M inhibitor
2017 · Jaebong Jang, Jung Beom Son, et al. · European Journal of Medicinal Chemistry · 48
Identification of Existing Drugs That Effectively Target NTRK1 and ROS1 Rearrangements in Lung Cancer
2016 · Curtis R. Chong, Magda Bahcall, et al. · Clinical Cancer Research · 81
Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation
2015 · John M. Hatcher, Magda Bahcall, et al. · Journal of Medicinal Chemistry · 43
Clinical Implications of Variant ALK FISH Rearrangement Patterns
2015 · Xin Gao, Lynette M. Sholl, et al. · Journal of Thoracic Oncology · 57
Efficacy of a Cancer Vaccine against ALK -Rearranged Lung Tumors
2015 · Claudia Voena, Matteo Menotti, et al. · Cancer Immunology Research · 60
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A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer
2015 · Frederick H. Wilson, Cory M. Johannessen, et al. · Cancer Cell · 172
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Identification and Characterization of ALK Kinase Splicing Isoforms in Non–Small-Cell Lung Cancer
2014 · Lorena Lobo de Figueiredo-Pontes, Daisy Wing-Sze Wong, et al. · Journal of Thoracic Oncology · 18
Co-Clinical Trials Demonstrate Superiority of Crizotinib to Chemotherapy in ALK -Rearranged Non–Small Cell Lung Cancer and Predict Strategies to Overcome Resistance
2013 · Zhao Chen, Esra Akbay, et al. · Clinical Cancer Research · 59
The ALKF1174L Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma
2012 · Teeara Berry, William Luther, et al. · Cancer Cell · 326
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Crizotinib for ALK-Rearranged Non–Small Cell Lung Cancer: A New Targeted Therapy for a New Target
2012 · Leena Gandhi, Pasi A. Jänne · Clinical Cancer Research · 84
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies
2012 · Doron Lipson, Marzia Capelletti, et al. · Nature Medicine · 865
New Strategies for Treatment of ALK-Rearranged Non–Small Cell Lung Cancers
2011 · Takaaki Sasaki, Pasi A. Jänne · Clinical Cancer Research · 75
Activation of ERBB2 Signaling Causes Resistance to the EGFR-Directed Therapeutic Antibody Cetuximab
2011 · Kimio Yonesaka, Kreshnik Zejnullahu, et al. · Science Translational Medicine · 663
A Novel ALK Secondary Mutation and EGFR Signaling Cause Resistance to ALK Kinase Inhibitors
2011 · Takaaki Sasaki, Jussi Koivunen, et al. · Cancer Research · 597
Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in Cancer
2011 · Xuemei Yang, Alexa B. Turke, et al. · Cancer Research · 14
Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors
2011 · Xianming Deng, Jinhua Wang, et al. · ACS Medicinal Chemistry Letters · 30
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Cleome serrata (Cleomaceae): nueva planta hospedera de tres especies de lepidópteros (Lepidoptera: Pieridae, Crambidae) en Cuba
2011 · Luis F. de Armas, Rayner Núñez Águila · Boletín de la SEA
The Neuroblastoma-Associated F1174L ALK Mutation Causes Resistance to an ALK Kinase Inhibitor in ALK-Translocated Cancers
2010 · Takaaki Sasaki, Katsuhiro Okuda, et al. · Cancer Research · 335
Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
2010 · Eunice L. Kwak, Yung-Jue Bang, et al. · New England Journal of Medicine · 4,447
Crizotinib in ALK -Rearranged Inflammatory Myofibroblastic Tumor
2010 · James E. Butrynski, David R. D'Adamo, et al. · New England Journal of Medicine · 870
Inhibition of ALK, PI3K/MEK, and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene
2010 · Zhao Chen, Takaaki Sasaki, et al. · Cancer Research · 191
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