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Neural Specification of Embryonic Stem Cells

Description: The proposed study will reveal how the transition from human embryonic stem cells to neural stem cells is regulated at the genetic and epigenetic levels. Understanding the molecular regulators in directing the fate of neural stem cells will significantly expand our ability to instigate regeneration of our aging and/or diseased brain.

Funder: National Institute of Neurological Disorders and Stroke

Funding type: research

Funder scheme: R01

Start date: 2003-02-01

End date: 2015-04-30

Investigator: SU-CHUN ZHANG

Institution: UNIVERSITY OF WISCONSIN-MADISON

Funded outputs count: 61

Funder award ID: R01NS045926

OpenAlex ID: G5198294765

Neural Subtype Specification from Human Pluripotent Stem Cells

2016 · Yunlong Tao, Su-Chun Zhang · Cell stem cell · 287

Time-Course Gene Expression Profiling Reveals a Novel Role of Non-Canonical WNT Signaling During Neural Induction

2016 · Cindy Tzu-Ling Huang, Yunlong Tao, et al. · Scientific Reports · 21

Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease

2016 · Yuejun Chen, Man Xiong, et al. · Cell stem cell · 158

Engineering human cells and tissues through pluripotent stem cells

2016 · Jeffrey R Jones, Su-Chun Zhang · Current Opinion in Biotechnology · 13

Generation of serotonin neurons from human pluripotent stem cells

2015 · Jianfeng Lu, Xuefei Zhong, et al. · Nature Biotechnology · 164

Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability

2015 · Huisheng Liu, Jianfeng Lu, et al. · Scientific Reports · 63

Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9

2015 · Yuejun Chen, Jingyuan Cao, et al. · Cell stem cell · 158

Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells

2015 · Zhong-Wei Du, Hong Chen, et al. · Nature Communications · 458

Human-derived neural progenitors functionally replace astrocytes in adult mice

2015 · Hong Chen, Kun Qian, et al. · Journal of Clinical Investigation · 72

A Simple and Efficient System for Regulating Gene Expression in Human Pluripotent Stem Cells and Derivatives

2014 · Kun Qian, CindyTzu‐Ling Huang, et al. · Stem Cells · 120

Turning Reactive Glia into Functional Neurons in the Brain

2014 · Jianfeng Lu, Robert A. Bradley, et al. · Cell stem cell · 13

Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells

2013 · Yan Liu, Huisheng Liu, et al. · Nature Protocols · 302

Deficits in human trisomy 21 iPSCs and neurons

2013 · Jason P. Weick, Dustie L. Held, et al. · Proceedings of the National Academy of Sciences · 205

miR-200 and miR-96 families repress neural induction from human embryonic stem cells

2013 · Zhong-Wei Du, Li-Xiang Ma, et al. · Development · 65

Generation of Integration-free and Region-Specific Neural Progenitors from Primate Fibroblasts

2013 · Jianfeng Lu, Huisheng Liu, et al. · Cell Reports · 105

Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits

2013 · Yan Liu, Jason P Weick, et al. · Nature Biotechnology · 277

Intracerebral Transplantation of Differentiated Human Embryonic Stem Cells to Hemiparkinsonian Monkeys

2013 · Marina E. Emborg, Zhijian Zhang, et al. · Cell Transplantation · 43

Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain

2013 · Marina E. Emborg, Yan Liu, et al. · Cell Reports · 146

Specification of Midbrain Dopamine Neurons from Primate Pluripotent Stem Cells

2012 · Jiajie Xi, Yan Liu, et al. · Stem Cells · 205

Human Embryonic Stem Cell-Derived GABA Neurons Correct Locomotion Deficits in Quinolinic Acid-Lesioned Mice

2012 · Lixiang Ma, Baoyang Hu, et al. · Cell stem cell · 293

Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network

2011 · Jason P. Weick, Yan Liu, et al. · Proceedings of the National Academy of Sciences · 83

Fibroblast Growth Factor Regulates Human Neuroectoderm Specification Through ERK1/2-PARP-1 Pathway

2011 · Young Dong Yoo, Cindy T. Huang, et al. · Stem Cells · 42

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

2011 · Robert Krencik, Su-Chun Zhang · Nature Protocols · 300

Specification of neuronal and glial subtypes from human pluripotent stem cells

2011 · Huisheng Liu, Su-Chun Zhang · Cellular and Molecular Life Sciences · 144

Specification of transplantable astroglial subtypes from human pluripotent stem cells

2011 · Robert Krencik, Jason P Weick, et al. · Nature Biotechnology · 407