Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
Description: Project Narrative. Relevance The primary objective of this project is to understand how prion diseases are spread between animals. The results of this study will provide a description of how prions can naturally enter the body from an external source, affect lymphoid tissue and then spread via nerves to the central nervous system where they cause fatal diseases such as chronic wasting disease in deer and elk, and scrapie in sheep. The results of this study will have implications for understanding the pathogenesis of other prion diseases such as bovine spongiform encephalopathy in cattle (mad cow disease) and variant Creutzfeldt-Jakob disease in humans.
Funding type: research
Funder scheme: R01
Start date: 2009-07-01
End date: 2015-06-30
Investigator: ANTHONY E. KINCAID
Institution: CREIGHTON UNIVERSITY
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 7
Funder award ID: R01NS061994
OpenAlex ID: G5219081280