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Optimization HIV Inhibition by Allosteric Integrase Inhibitors

Description: Project narrative The scientific premise of the proposed research is that we can use structural and functional studies of HIV integrase to optimize effectiveness a new class of inhibitors.
Funding type: research
Funder scheme: R01
Start date: 2017-01-17
End date: 2022-12-31
Field: Medicine
Funded outputs count: 10
Funder award ID: R01AI129661
OpenAlex ID: G5259589433
Structural Impact of Ex Vivo Resistance Mutations on HIV-1 Integrase Polymers Induced by Allosteric Inhibitors
2025 · Saira Montermoso, Grant Eilers, et al. · Journal of Molecular Biology · 5
Proviral location affects cognate peptide–induced virus production and immune recognition of HIV-1–infected T cell clones
2023 · Filippo Dragoni, Abena K. Kwaa, et al. · Journal of Clinical Investigation · 28
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2-Hydroxyisovalerate Is Produced During Bacterial Vaginosis and Boosts HIV Infection in Resting T Cells
2023 · Kaitlin A. Marquis, Carter Merenstein, et al. · AIDS Research and Human Retroviruses · 2
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The HIV-1 Capsid-Targeted Inhibitor GSK878 Alters Selection of Target Sites for HIV DNA Integration
2023 · Kaitlin A. Marquis, John Everett, et al. · AIDS Research and Human Retroviruses · 8
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Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization
2023 · Grant Eilers, Kushol Gupta, et al. · PLoS Pathogens · 11
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Allosteric HIV Integrase Inhibitors Promote Formation of Inactive Branched Polymers via Homomeric Carboxy-Terminal Domain Interactions
2020 · Kushol Gupta, Audrey Allen, et al. · Structure · 20
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Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo
2020 · Francesco R. Simonetti, Hao Zhang, et al. · Journal of Clinical Investigation · 169
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Assessment of HIV-1 integration in tissues and subsets across infection stages
2020 · Vincent H. Wu, Christopher L. Nobles, et al. · JCI Insight · 21
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Influence of the amino-terminal sequence on the structure and function of HIV integrase
2020 · Grant Eilers, Kushol Gupta, et al. · Retrovirology · 10
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Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase
2016 · Kushol Gupta, Vesa Turkki, et al. · PLoS Biology · 71
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