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Dynamics of Ribosomal Protein Synthesis

Funding type: research
Funder scheme: R01
Start date: 2004-04-01
End date: 2013-07-31
Investigator: BARRY S. COOPERMAN
Institution: UNIVERSITY OF PENNSYLVANIA
Funded outputs count: 27
Funder award ID: R01GM071014
OpenAlex ID: G5319085086
Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis
2011 · Chunlai Chen, Benjamin Stevens, et al. · Proceedings of the National Academy of Sciences · 70
The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis
2011 · Hanqing Liu, Chunlai Chen, et al. · Proceedings of the National Academy of Sciences · 45
Quantitative single cell monitoring of protein synthesis at subcellular resolution using fluorescently labeled tRNA
2011 · Sima Barhoom, Jaskiran Kaur, et al. · Nucleic Acids Research · 40
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Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding
2011 · Cuiping Liu, Howard Gamper, et al. · Nature Communications · 23
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Fluorescent labeling of tRNA dihydrouridine residues: Mechanism and distribution
2011 · Jaskiran Kaur, Monika Raj, et al. · RNA · 35
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Single-Molecule Fluorescence Measurements of Ribosomal Translocation Dynamics
2011 · Chunlai Chen, Benjamin Stevens, et al. · Molecular Cell · 138
Differential Effects of Thiopeptide and Orthosomycin Antibiotics on Translational GTPases
2011 · Aleksandra Mikolajka, Hanqing Liu, et al. · Chemistry & Biology · 43
Probing Translation with Small-Molecule Inhibitors
2010 · Scott C. Blanchard, Barry S. Cooperman, et al. · Chemistry & Biology · 44
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Signal transduction on the ribosome:timing EF‐Tu release from aminoacyl‐tRNA
2010 · Wei Liu, Kiran Poruri, et al. · The FASEB Journal
Interrupted catalysis: the EF4 (LepA) effect on back translocation
2010 · Hanqing Liu, Dongli Pan, et al. · The FASEB Journal
Interrupted Catalysis: The EF4 (LepA) Effect on Back-Translocation
2010 · Hanqing Liu, Dongli Pan, et al. · Journal of Molecular Biology · 43
Identification of Distinct Thiopeptide-Antibiotic Precursor Lead Compounds Using Translation Machinery Assays
2009 · Agata L. Starosta, Haiou Qin, et al. · Chemistry & Biology · 26
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Interaction of IF2 with the Ribosomal GTPase-Associated Center during 70S Initiation Complex Formation
2009 · Haiou Qin, Christina Grigoriadou, et al. · Biochemistry · 29
Synthesis and functional activity of tRNAs labeled with fluorescent hydrazides in the D-loop
2008 · Dongli Pan, Haiou Qin, et al. · RNA · 60
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Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3′ end
2008 · Chun-Mei Zhang, Cuiping Liu, et al. · RNA · 20
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Fast in vitro translation system immobilized on a surface via specific biotinylation of the ribosome
2008 · Romualdas Stapulionis, Yuhong Wang, et al. · Biological Chemistry · 6
Role of hybrid tRNA-binding states in ribosomal translocation
2008 · Sarah E. Walker, Shinichiro Shoji, et al. · Proceedings of the National Academy of Sciences · 77
Perturbation of the tRNA Tertiary Core Differentially Affects Specific Steps of the Elongation Cycle
2008 · Dongli Pan, Chun-Mei Zhang, et al. · Journal of Biological Chemistry · 27
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Single-Molecule Structural Dynamics of EF-G−Ribosome Interaction during Translocation
2007 · Yuhong Wang, Haiou Qin, et al. · Biochemistry · 66
The Translational Fidelity Function of IF3 During Transition from the 30 S Initiation Complex to the 70 S Initiation Complex
2007 · Christina Grigoriadou, Stefano Marzi, et al. · Journal of Molecular Biology · 74
A Quantitative Kinetic Scheme for 70 S Translation Initiation Complex Formation
2007 · Christina Grigoriadou, Stefano Marzi, et al. · Journal of Molecular Biology · 92
Fluorescent labeling of tRNAs for dynamics experiments
2007 · Thu Betteridge, Hanqing Liu, et al. · RNA · 36
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Kinetically Competent Intermediates in the Translocation Step of Protein Synthesis
2007 · Dongli Pan, Stanislav V. Kirillov, et al. · Molecular Cell · 189
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Rapid ribosomal translocation depends on the conserved 18-55 base pair in P-site transfer RNA
2006 · Dongli Pan, Stanislav Kirillov, et al. · Nature Structural & Molecular Biology · 54
EF-G-Dependent GTPase on the Ribosome. Conformational Change and Fusidic Acid Inhibition
2006 · Hyuk-Soo Seo, Sameem Abedin, et al. · Biochemistry · 72
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