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The molecular basis of planarian regeneration

Funding type: research
Funder scheme: R37
Start date: 1998-05-01
End date: 2021-05-31
Investigator: ALEJANDRO SANCHEZ ALVARADO
Institution: STOWERS INSTITUTE FOR MEDICAL RESEARCH
Funded outputs count: 61
Funder award ID: R37GM057260
OpenAlex ID: G5368705147
Syrah: a pipeline to maximize spatial transcriptomics data output
2026 · Carolyn Brewster, Frederick G Mann, et al. · G3 Genes Genomes Genetics · 4
Metabolites produced by agat+ cells support regeneration in the planarian Schmidtea mediterranea
2025 · Aubrey M. Kent, Carlos Guerrero-Hernández, et al. · Developmental Biology · 3
Molecular and cellular characterization of planarian stem cell microenvironments
2025 · Frederick G. Mann, Carolyn E. Brewster, et al. · Cell Reports · 4
Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells
2025 · Prince Verma, John M. Allen, et al. · BMC Genomics · 2
Oogenesis involves a novel nuclear envelop remodeling mechanism in Schmidtea mediterranea
2024 · Longhua Guo, Fengli Guo, et al. · Developmental Biology · 2
A PAK family kinase and the Hippo/Yorkie pathway modulate WNT signaling to functionally integrate body axes during regeneration
2024 · Viraj Doddihal, Frederick G. Mann, et al. · Proceedings of the National Academy of Sciences · 16
Pluripotency retention and exogenous mRNA introduction in planarian stem cells in culture
2023 · Kai Lei, Wenya Zhang, et al. · iScience · 26
Molecular characterization of a flatworm Girardia isolate from Guanajuato, Mexico
2022 · Elizabeth M. Duncan, Stephanie H. Nowotarski, et al. · Developmental Biology · 6
Developmental biology is poised to discover altogether new principles in biology in the 21st century
2022 · Alejandro Sánchez Alvarado · Developmental Biology · 5
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Planarians employ diverse and dynamic stem cell microenvironments to support whole-body regeneration
2022 · Blair W. Benham-Pyle, Frederick G. Mann, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 10
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Hox genes regulate asexual reproductive behavior and tissue segmentation in adult animals
2021 · Christopher P. Arnold, Analí Migueles Lozano, et al. · Nature Communications · 32
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Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea
2021 · Blair W. Benham-Pyle, Carolyn E. Brewster, et al. · Nature Cell Biology · 71
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Planarian Anatomy Ontology: a resource to connect data within and across experimental platforms
2021 · Stephanie H. Nowotarski, Erin L. Davies, et al. · Development · 18
Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates
2020 · Wei Wang, Chi-Kuo Hu, et al. · Science · 214
Planarians recruit piRNAs for mRNA turnover in adult stem cells
2019 · Iana V. Kim, Elizabeth M. Duncan, et al. · Genes & Development · 50
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Regulation of Genomic Output and (Pluri)potency in Regeneration
2019 · Elizabeth M. Duncan, Alejandro Sánchez Alvarado · Annual Review of Genetics · 17
Wnt and TGFβ coordinate growth and patterning to regulate size-dependent behaviour
2019 · Christopher P. Arnold, Blair W. Benham-Pyle, et al. · Nature · 66
Subcellular analyses of planarian meiosis implicates a novel, double-membraned vesiculation process in nuclear envelope breakdown
2019 · Longhua Guo, Fengli Guo, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Prospectively Isolated Tetraspanin+ Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration
2018 · An Zeng, Hua Li, et al. · Cell · 277
A nuclear hormone receptor and lipid metabolism axis are required for the maintenance and regeneration of reproductive organs
2018 · Shasha Zhang, Longhua Guo, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
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Culturing Planarians in the Laboratory
2018 · M. Shane Merryman, Alejandro Sánchez Alvarado, et al. · Methods in molecular biology · 66
Whole-Mount BrdU Staining with Fluorescence In Situ Hybridization in Planarians
2018 · Li-Chun Cheng, Alejandro Sánchez Alvarado · Methods in molecular biology · 9
Planarians and the History of Animal Regeneration: Paradigm Shifts and Key Concepts in Biology
2018 · Sarah A. Elliott, Alejandro Sánchez Alvarado · Methods in molecular biology · 19
To solve old problems, study new research organisms
2017 · Alejandro Sánchez Alvarado · Developmental Biology · 25
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Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarian Schmidtea mediterranea
2017 · Li-Chun Cheng, Kimberly C. Tu, et al. · Developmental Biology · 47
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